Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKM? and increased ?OR in the hippocampus of female mice

Basit Öğe Kaydı
dc.authoridAbdurrahman Aslan / 0000-0002-6730-4768en_US
dc.authorscopusidAbdurrahman Aslan / 57284573900
dc.contributor.authorAvila, Jorge A
dc.contributor.authorMemos, Nicoletta
dc.contributor.authorAslan, Abdurrahman
dc.contributor.authorAndrejewski, Tytus
dc.contributor.authorLuine, Victoria N
dc.contributor.authorSerrano, Peter A
dc.date.accessioned2021-10-06T11:57:46Z
dc.date.available2021-10-06T11:57:46Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractBackground: Female populations exhibit vulnerabilities to psychostimulant addiction, as well as cognitive dysfunction following bouts of abuse. Aims: The goal for this study was to advance our understanding of the mechanisms that produce sex disparities in drug addiction. Methods: We used an animal model for voluntary oral methamphetamine administration (VOMA) and focused on male and female mice that consumed 7.6-8.2 mg/kg of methamphetamine (MA) per day during the last 18 days of the paradigm. Results: The VOMA-exposed female mice displayed increased locomotor activity in the drug-administration context compared to male mice, demonstrating sex-specific changes in contextual sensitization. During 2 weeks of forced abstinence, mice underwent further behavioral testing. We show that abstinence increased open-arm entries on the elevated plus maze in both sexes. There were no differences in immobility on the tail suspension test. In a hippocampal-dependent radial arm maze task, VOMA-treated female mice, but not male mice, showed working memory deficits. Hippocampal tissue was collected and analyzed using Western blotting. VOMA-exposed female mice exhibited increased kappa opioid receptor (?OR) expression in the hippocampus compared to male mice, suggesting a vulnerability toward abstinence-induced dysphoria. Female VOMA mice also exhibited a decrease in the memory protein marker, protein kinase M zeta (PKM?), in the hippocampus. Conclusions: Our study reveals sex-specific effects following abstinence from chronic MA consumption on hippocampal ?OR and PKM? expression, suggesting that these neural changes in female mice may underlie spatial memory deficits and identify an increased susceptibility to dysregulated neural mechanisms. These data validate VOMA as a model sensitive to sex differences in behavior and hippocampal neurochemistry following chronic MA exposure.en_US
dc.identifier.citationAvila, J. A., Memos, N., Aslan, A., Andrejewski, T., Luine, V. N., & Serrano, P. A. (2021). Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKMζ and increased κOR in the hippocampus of female mice. Journal of psychopharmacology (Oxford, England), 2698811211048285. Advance online publication. https://doi.org/10.1177/02698811211048285en_US
dc.identifier.doi10.1177/02698811211048285en_US
dc.identifier.pmid34587831en_US
dc.identifier.scopus2-s2.0-85116322118en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2121
dc.identifier.wosWOS:000704028600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAslan, Abdurrahman
dc.language.isoenen_US
dc.publisherSage Journalsen_US
dc.relation.ispartofJournal of Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHippocampusen_US
dc.subjectAddictionen_US
dc.subjectKappa Opiate Receptoren_US
dc.subjectProtein Kinase M Zetaen_US
dc.subjectSex Differencesen_US
dc.titleVoluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKM? and increased ?OR in the hippocampus of female miceen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Eczacılık Meslek Bilimleri Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu