Noncoding RNAs and their therapeutics in paclitaxel chemotherapy: Mechanisms of initiation, progression, and drug sensitivity

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorMahabady, Mahmood K.
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorSaebfar, Hamidreza
dc.contributor.authorGholami, Mohammad H.
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorHashemi, Farid
dc.contributor.authorTajik, Fatemeh
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorKumar, Alan P.
dc.contributor.authorAref, Amir R.
dc.contributor.authorZarrabi, Ali
dc.contributor.authorKhan, Haroon
dc.contributor.authorHamblin, Michael R.
dc.contributor.authorErtas, Yavuz Nuri
dc.contributor.authorSamarghandian, Saeed
dc.date.accessioned2022-06-03T14:10:24Z
dc.date.available2022-06-03T14:10:24Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractThe identification of agents that can reverse drug resistance in cancer chemotherapy, andenhance the overall efficacy is of great interest. Paclitaxel (PTX) belongs to taxane family hat exerts an antitumor effect by stabilizing microtubules and inhibiting cell cycleprogression. However, PTX resistance often develops in tumors due to the over-expression of drug transporters and tumor?promoting pathways. Noncoding RNAs(ncRNAs) are modulators of many processes in cancer cells, such as apoptosis, migration,differentiation, and angiogenesis. In the present study, we summarize the effects ofncRNAs on PTX chemotherapy. MicroRNAs (miRNAs) can have opposite effects on PTXresistance (stimulation or inhibition) via influencing YES1, SK2, MRP1, and STAT3.Moreover, miRNAs modulate the growth and migration rates of tumor cells in regulatingPTX efficacy. PIWI?interacting RNAs, small interfering RNAs, and short?hairpin RNAs areother members of ncRNAs regulating PTX sensitivity of cancer cells. Long noncodingRNAs (LncRNAs) are similar to miRNAs and can modulate PTX resistance/sensitivity bytheir influence on miRNAs and drug efflux transport. The cytotoxicity of PTX againsttumor cells can also be affected by circular RNAs (circRNAs) and limitation is thatoncogenic circRNAs have been emphasized and experiments should also focus on onco?suppressor circRNAs.en_US
dc.identifier.citationMahabady MK, Mirzaei S, Saebfar H, Gholami MH, Zabolian A, Hushmandi K, Hashemi F, Tajik F, Hashemi M, Kumar AP, Aref AR, Zarrabi A, Khan H, Hamblin MR, Nuri Ertas Y, Samarghandian S. Noncoding RNAs and their therapeutics in paclitaxel chemotherapy: Mechanisms of initiation, progression, and drug sensitivity. J Cell Physiol. 2022 May;237(5):2309-2344. doi: 10.1002/jcp.30751. Epub 2022 Apr 18. PMID: 35437787.en_US
dc.identifier.doi10.1002/jcp.30751en_US
dc.identifier.endpage2344en_US
dc.identifier.issn0021-9541en_US
dc.identifier.issue5en_US
dc.identifier.pmid35437787en_US
dc.identifier.scopus2-s2.0-85128283127en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2309en_US
dc.identifier.urihttp://doi.org/10.1002/jcp.30751
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2792
dc.identifier.volume237en_US
dc.identifier.wosWOS:000783351900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cellular Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCircular RNAen_US
dc.subjectLong Noncoding RNAen_US
dc.subjectMiRNAen_US
dc.subjectPaclitaxelen_US
dc.subjectShort‐Hairpin RNAen_US
dc.subjectSmall Interfering RNAen_US
dc.titleNoncoding RNAs and their therapeutics in paclitaxel chemotherapy: Mechanisms of initiation, progression, and drug sensitivityen_US
dc.typeArticleen_US

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