Development and in vitro evaluation of biocompatible pla-based trilayer nanofibrous membranes for the delivery of nanoceria: a novel approach for diabetic wound healing

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dc.authoridGökçe Erdemir / 0000-0002-6476-2421en_US
dc.authorscopusidGökçe Erdemir / 57207566355en_US
dc.authorwosidGökçe Erdemir / AAS-4648-2021
dc.contributor.authorHussein, Mohamed Ahmed Mohamady
dc.contributor.authorSu, Sena
dc.contributor.authorUlag, Songul
dc.contributor.authorWo?niak, Agata
dc.contributor.authorGrinholc, Mariusz Stanislaw
dc.contributor.authorErdemir, Gökçe
dc.date.accessioned2021-11-08T07:15:06Z
dc.date.available2021-11-08T07:15:06Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe attempts to explore and optimize the efficiency of diabetic wound healing’s promotors are still in progress. Incorporation of cerium oxide nanoparticles (nCeO2) in appropriate nanofibers (NFs) can prolong and maximize their promoting effect for the healing of diabetic wounds, through their sustained releases, as well as the nanofibers role in mimicking of the extra cellular matrix (ECM). The as-prepared nCeO2 were analyzed by using UV–Vis spectroscopy, XRD, SEM–EDX, TEM and FTIR, where TEM and SEM images of both aqueous suspension and powder showed spherical/ovoidshaped particles. Biodegradable trilayer NFs with cytobiocompatibility were developed to sandwich nCeO2 in PVA NFs as a middle layer where PLA NFs were electrospun as outer bilayer. The nCeO2 loaded trilayer NFs were characterized by SEM, XRD, FTIR and DSC. A two-stage release behavior was observed when the nanoceria was released from the trilayer-based nanofibers; an initial burst release took place, and then it was followed by a sustained release pattern. The mouse embryo fibroblasts, i.e., 3T3 cells, were seeded over the nCeO2-loaded NFs mats to investigate their cytobiocompatibility. The presence and sustained release of nCeO2 efficiently enhance the adhesion, growth and proliferation of the fibroblasts’ populations. Moreover, the incorporation of nCeO2 with a higher amount into the designed trilayer NFs demonstrated a significant improvement in morphological, mechanical, thermal and cyto-biocompatibility properties than lower doses. Overall, the obtained results suggest that designated trilayer nanofibrous membranes would offer a specific approach for the treatment of diabetic wounds through an effective controlled release of nCeO2. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.identifier.citationHussein, M. A. M., Su, S., Ulag, S., Woźniak, A., Grinholc, M., Erdemir, G., ... & Megahed, M. (2021). Development and In Vitro Evaluation of Biocompatible PLA-Based Trilayer Nanofibrous Membranes for the Delivery of Nanoceria: A Novel Approach for Diabetic Wound Healing. Polymers, 13(21), 3630.en_US
dc.identifier.doi10.3390/polym13213630en_US
dc.identifier.endpage19en_US
dc.identifier.issn2073-4360en_US
dc.identifier.issue21en_US
dc.identifier.pmid34771187en_US
dc.identifier.scopus2-s2.0-85117898475en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3390/polym13213630
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2201
dc.identifier.volume13en_US
dc.identifier.wosWOS:000718855400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdemir, Gökçe
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPolymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetic Wound Healingen_US
dc.subjectFibroblastsen_US
dc.subjectNanoceriaen_US
dc.subjectPLA-based Trilayer Nanofibrous Membranesen_US
dc.subjectPVAen_US
dc.titleDevelopment and in vitro evaluation of biocompatible pla-based trilayer nanofibrous membranes for the delivery of nanoceria: a novel approach for diabetic wound healingen_US
dc.typeArticleen_US

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