Antimicrobial activity of blow spun PLA/gelatin nanofibers containing green synthesized silver nanoparticles against wound ınfection-causing bacteria

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dc.authoridAtefeh Zarepour / 0000-0002-0347-5840en_US
dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAtefeh Zarepour / 56700291100en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAtefeh Zarepour / AAH-9225-2020en_US
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorSardareh, Elham Alinezhad
dc.contributor.authorShahzeidi, Moloud
dc.contributor.authorArdestani, Mohammad Taha Salmanifard
dc.contributor.authorMousavi-Khattat, Mohammad
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2022-11-12T07:20:45Z
dc.date.available2022-11-12T07:20:45Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractOne of the main challenges in wound healing is the wound infection due to various causes, of which moisture is the most important reason. Owing to this fact, wound dressings that can collect wound moisture in addition to showing antibacterial properties have provided an important basis for wound healing research. In this study, gelatin and poly lactic acid (PLA) polymers were used in a wound dressing textile to provide gelation and structure strength properties, respectively. Meanwhile, silver nanoparticles (SNPs) synthesized through the green method were integrated into these fibers to provide the formed textile with antibacterial properties. Nanoparticles were made using donkey dung extract, and nanofibers were produced by the solution blow spinning method which has high production efficiency and low energy consumption among spinning methods. The produced nanoparticles were characterized and evaluated by UV-Vis, DLS, XRD, and FTIR methods, and the production of silver nanoparticles that were coated with metabolites in the extract was proven. In addition, the morphology and diameter of the resulted fibers and presence of nanoparticles were confirmed by the SEM method. The size and size distribution of the synthesized fibers were determined through analyzing SEM results. Gelatin nanofibers demonstrated a mean size of 743 nm before and 773 nm after nanoparticle coating. PLA nanofibers demonstrated a mean size of 57 nm before and 182 nm after nanoparticle coating. Finally, 335 nm was the mean diameter size of gelatin/PLA/SNPs nanofibers. Also, the textiles synthesized by PLA and gelatin which contained silver nanoparticles showed higher antibacterial activity against both gram-positive and gram-negative species compared to PLA and gelatin tissues without nanoparticles. Cytotoxicity test on L929 cells showed that silver nanoparticles incorporated textiles of PLA and gelatin show a very low level and non-significant toxicity compared to the free particles.en_US
dc.identifier.citationAlinezhad Sardareh, E., Shahzeidi, M., Salmanifard Ardestani, M. T., Mousavi-Khattat, M., Zarepour, A., & Zarrabi, A. (2022). Antimicrobial Activity of Blow Spun PLA/Gelatin Nanofibers Containing Green Synthesized Silver Nanoparticles against Wound Infection-Causing Bacteria. Bioengineering, 9(10), 518.en_US
dc.identifier.doi10.3390/bioengineering9100518en_US
dc.identifier.issn2306-5354en_US
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85140385435en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://dx.doi.org/10.3390/bioengineering9100518
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3348
dc.identifier.volume9en_US
dc.identifier.wosWOS:000874181400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarepour, Atefeh
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBIOENGINEERING-BASELen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNanofibersen_US
dc.subjectSolution Blow Spinningen_US
dc.subjectHemolysisen_US
dc.subjectPLAen_US
dc.subjectGelatinen_US
dc.subjectAntibacterialen_US
dc.subjectCytotoxicity Green Ag Nanoparticlesen_US
dc.subjectCell Viabilityen_US
dc.titleAntimicrobial activity of blow spun PLA/gelatin nanofibers containing green synthesized silver nanoparticles against wound ınfection-causing bacteriaen_US
dc.typeArticleen_US

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