Antibody Response to COVID-19 Vaccines in Healthcare Workers: Which One is More Successful? Homologous or Heterologous?

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dc.contributor.authorKarakoc, Zehra Cagla
dc.contributor.authorTascioglu, Didem
dc.contributor.authorEdiz, Bulent
dc.contributor.authorCaglan, Musa
dc.contributor.authorHancer, Veysel Sabri
dc.contributor.authorTugrul, Tolga Simru
dc.contributor.authorSimsek, Binnur Pinarbasi
dc.date.accessioned2024-05-19T14:39:03Z
dc.date.available2024-05-19T14:39:03Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: We aimed to determine the antibody levels created by COVID-19 vaccination in healthcare workers and the factors affecting the antibody response.Methods: Our research is a single-center, observational study that was prospectively designed and retrospectively analyzed at the beginning of the COVID-19 pandemic, and included 103 healthcare workers who received the three-dose regimen of COVID-19 vaccine. In accordance with the recommendations of the Ministry of Health of Turkey, the first two doses of CoronaVac vaccine were administered routinely, while the booster dose was given as BioNTech or CoronaVac (heterologous or homologous vaccination) depending on the preference of the volunteers. Antibody titers against the SARS-CoV-2 were measured in all individuals at different time points (1 month after the second dose of CoronaVac, before the booster dose [BioNTech or CoronaVac] at the fifth month and one month after the booster dose) with AESKULISA & REG; SARS-CoV-2 S1 IgG (AESKU DIAGNOSTICS, Wendelsheim, Germany).Results: The mean age was 39.98 & PLUSMN;11.31 years, 62.1% of whom were women and 54.4% of them were accompanied by comorbid disease. After two doses of CoronaVac, the antibody titer averaged 49.50 & PLUSMN;33.15 U/mL in the 1st month (antibody seropositivity 86%) and the antibody titer decreased 24.01 & PLUSMN;33.48 U/mL (antibody seropositivity 49.5%) at 5th month. The mean antibody titer was found 59.73 & PLUSMN;60.20 U/ml in those who received the booster dose of homologous and 185.07 & PLUSMN;46.28 U/mL in those who were heterologous (p<0.001). Antibody levels were detected significantly lower after the booster dose of vaccination in patients with Conclusion: Our study, which reflects the data within the scope of the Turkey Ministry of Health's COVID-19 vaccination program determined that the antibody response after heterologous vaccination is better than in homologous vaccination. Antibody titer but after the booster dose antibody levels decreased significantly in those with comorbidity.en_US
dc.description.sponsorshipIstinye Uni-versity Scientific Research Projects fund [2021/B19]en_US
dc.description.sponsorshipFinancial support: Our work was supported by the Istinye Uni-versity Scientific Research Projects fund (Project number: 2021/B19) .en_US
dc.identifier.doi10.14744/SEMB.2023.48264
dc.identifier.endpage223en_US
dc.identifier.issn1302-7123
dc.identifier.issn1308-5123
dc.identifier.issue2en_US
dc.identifier.pmid37899804en_US
dc.identifier.startpage216en_US
dc.identifier.trdizinid1185901en_US
dc.identifier.urihttps://doi.org10.14744/SEMB.2023.48264
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1185901
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4687
dc.identifier.volume57en_US
dc.identifier.wosWOS:001021864200010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofMedical Bulletin of Sisli Etfal Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAntibodyen_US
dc.subjectCovid-19en_US
dc.subjectHealth-Care Workersen_US
dc.subjectSars-Cov-2en_US
dc.subjectVaccineen_US
dc.titleAntibody Response to COVID-19 Vaccines in Healthcare Workers: Which One is More Successful? Homologous or Heterologous?en_US
dc.typeArticleen_US

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