A novel autologous dermal filler based on cultured fibroblasts and plasma gel for facial wrinkles: Long term results

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dc.authoridAyşe Deniz Akkaya / 0000-0001-8884-1602
dc.authorscopusidAyşe Deniz Akkaya / 25225190600
dc.authorwosidAyşe Deniz Akkaya / H-2471-2017
dc.date.accessioned2022-01-18T08:43:54Z
dc.date.available2022-01-18T08:43:54Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAutologous cultured fibroblasts combined with plasma gel (Fibrogel(TM)) can be used as an injectable autologous soft tissue filler. Herein, we report the assessment of the long-term clinical efficacy and safety of Fibrogel for facial wrinkles. Ten healthy adults were treated for facial wrinkles with Fibrogel, an innovative autologous filler. Patients underwent three treatment sessions at 1-month intervals for the correction of infraorbital, nasolabial, and marionette folds. In each session, 6-8 mL of Fibrogel filler containing 4 million fibroblasts/mL, was injected into the deep dermis or subdermal plane. Three evaluators independently assessed the efficacy at 3, 6 and 12 months after the last treatment, using the validated Global Esthetic Improvement Scale at two different times in a blinded manner. Infraorbital area and lower face were evaluated separately. All patients showed immediate improvement after the first injection at the infraorbital area and lower face. Follow-ups at 3, 6 and 12 months revealed that the improvement was persistent. Adverse reactions were mild and the treatment was well tolerated. Delivering autologous cultured fibroblasts embedded in an autologous plasma gel (Fibrogel) to the skin can provide immediate volume effect and long-term improvement. Therefore, Fibrogel can be considered as a promising novel autologous filler.en_US
dc.identifier.citationOram, Y., Deniz Akkaya, A., Güneren, E., & Turgut, G. (2022). A novel autologous dermal filler based on cultured fibroblasts and plasma gel for facial wrinkles: Long term results. Journal of Cosmetic and Laser Therapyen_US
dc.identifier.doi10.1080/14764172.2021.2009876en_US
dc.identifier.issn1476-4172en_US
dc.identifier.pmid34978247en_US
dc.identifier.scopus2-s2.0-85122269177en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/14764172.2021.2009876
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2393
dc.identifier.wosWOS:000737735800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkkaya, Ayşe Deniz
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofJournal of Cosmetic and Laser Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutologous filleren_US
dc.subjectSkin rejuvenationen_US
dc.subjectFibroblast cultureen_US
dc.subjectFibroblastsen_US
dc.subjectPlasma gelen_US
dc.titleA novel autologous dermal filler based on cultured fibroblasts and plasma gel for facial wrinkles: Long term resultsen_US
dc.typeArticleen_US

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