Oral biofluid levels of activin-a and interleukin-1beta in stage III periodontitis

Basit Öğe Kaydı
dc.authorscopusidGülnur Emingil / 35609889700
dc.authorwosidGülnur Emingil / IRR-0557-2023
dc.contributor.authorÖzden, Can
dc.contributor.authorAfacan, Beral
dc.contributor.authorİlhan, Harika Atmaca
dc.contributor.authorKöse, Timur
dc.contributor.authorEmingil, Gülnur
dc.date.accessioned2025-04-17T08:41:03Z
dc.date.available2025-04-17T08:41:03Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü
dc.description.abstractObjectives Activin-A belongs to the transforming growth factor-beta superfamily and is a multifunctional cytokine that plays a role in inflammation, immune response, tissue repair and regeneration. Proinflammatory cytokine interleukin-1beta (IL-1 beta) can increase Activin-A expression in various cell types. This study aims to evaluate gingival crevicular fluid (GCF) and salivary Activin-A and IL-beta levels in stage III periodontitis. Materials and methods 23 patients with stage III periodontitis, 26 with gingivitis and 26 periodontally healthy individuals were included. Full-mouth clinical periodontal indices were recorded, unstimulated whole saliva and GCF samples were obtained, Activin-A and IL-1 beta total amounts were determined by ELISA. Statistical comparisons were performed using non-parametric tests. Receiver operating characteristics curve was used for estimating the area under the curve (AUC). Results Periodontitis group exhibited significantly lower GCF Activin-A levels but higher IL-1 beta levels than the periodontally healthy group (p < 0.05). Gingivitis group had similar GCF Activin-A and IL-1 beta levels to the periodontitis and periodontally healthy groups (p > 0.05). Salivary Activin-A and IL-1 beta concentrations were similar among study groups (p > 0.05). GCF Activin-A level showed an excellent diagnostic performance (an AUC value of 0.82 with 87% sensitivity) to discriminate periodontitis from periodontal health. ConclusionsFor the first time, this study demonstrated oral biofluid levels of Activin-A in periodontal health and diseases. Within the limits of the study, it might be suggested that diseased sites in periodontitis are associated with reduced Activin-A and increased IL-1 beta levels in GCF.Clinical relevance.Reduced GCF Activin-A levels and the accompanying increase in IL-1 beta might be associated with diseased sites in stage III periodontitis. ConclusionsFor the first time, this study demonstrated oral biofluid levels of Activin-A in periodontal health and diseases. Within the limits of the study, it might be suggested that diseased sites in periodontitis are associated with reduced Activin-A and increased IL-1 beta levels in GCF.Clinical relevance.Reduced GCF Activin-A levels and the accompanying increase in IL-1 beta might be associated with diseased sites in stage III periodontitis. ConclusionsFor the first time, this study demonstrated oral biofluid levels of Activin-A in periodontal health and diseases. Within the limits of the study, it might be suggested that diseased sites in periodontitis are associated with reduced Activin-A and increased IL-1 beta levels in GCF.Clinical relevance.Reduced GCF Activin-A levels and the accompanying increase in IL-1 beta might be associated with diseased sites in stage III periodontitis.
dc.description.sponsorshipAydın Adnan Menderes University
dc.identifier.citationÖzden, C., Afacan, B., İlhan, H. A., Köse, T., & Emingil, G. (2025). Oral biofluid levels of Activin-A and interleukin-1beta in stage III periodontitis. Clinical Oral Investigations, 29(1), 1-11.
dc.identifier.doi10.1007/s00784-024-06088-1
dc.identifier.endpage11
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue1
dc.identifier.pmid39656274
dc.identifier.scopus2-s2.0-85211498528
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1007/s00784-024-06088-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6171
dc.identifier.volume29
dc.identifier.wosWOS:001375556200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEmingil, Gülnur
dc.institutionauthoridGülnur Emingil / 0000-0002-4869-9629
dc.language.isoen
dc.publisherSpringer science and business media deutschland GmbH
dc.relation.ispartofClinical oral investigations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCytokine
dc.subjectGingival Crevicular Fluid
dc.subjectInflammation
dc.subjectPeriodontitis
dc.subjectSaliva
dc.titleOral biofluid levels of activin-a and interleukin-1beta in stage III periodontitis
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
s00784-024-06088-1 (1).pdf
Boyut:
885.55 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Klinik Bilimler Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu