The anticancer potential of chlorine dioxide in small-cell lung cancer cells
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
CUREUS INC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background Chlorine dioxide (ClO2) is an effective disinfectant consisting of oxygen, chloride, and potassium. Because of its high oxidative capacity, ClO2 exerts antimicrobial, antiviral, and antifungal effects. However, its anticancer effects remain to be elucidated. Methodology The anticancer activity of ClO2 was assessed on DMS114 small-cell lung cancer (SCLC) cells and human umbilical vein endothelial cells (HUVEC) as control by WST-1, Annexin V, cell cycle analysis, and acridine orange staining. We for the first time investigated the possible therapeutic effects of long-term stabilized ClO2 solution (LTSCD). Results Our preliminary findings showed that LTSCD significantly inhibited the proliferation of SCLC cells (p < 0.01) with less toxicity in HUVEC cells. Additionally, LTSCD induced apoptotic cell death in SCLC cells through nuclear blehhing and vacuolar formation. However, LTSCD treatment did not induce cell cycle arrest in both cell lines. Conclusions LTSCD can be a therapeutic potential for the treatment of SCLC. However, further investigations are required to assess the LTSCD-induced cell death in SCLC both in vitro and in vivo.
Açıklama
Anahtar Kelimeler
Small-Cell Lung Cancer, Anticancer, Dms114 Cell Line, Apoptosis, Chlorine Dioxide
Kaynak
CUREUS JOURNAL OF MEDICAL SCIENCE
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
14
Sayı
10
Künye
Yıldız, S. Z., Bilir, C., Eskiler, G. G., & Bilir, F. (2022). The Anticancer Potential of Chlorine Dioxide in Small-Cell Lung Cancer Cells. Cureus, 14(10).
