The anticancer potential of chlorine dioxide in small-cell lung cancer cells

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dc.authoridCemil Bilir / 0000-0002-1372-4791en_US
dc.authorscopusidCemil Bilir / 23666163400
dc.authorwosidCemil Bilir / DTZ-3231-2022en_US
dc.contributor.authorYıldız, Salih Zeki
dc.contributor.authorBilir, Cemil
dc.contributor.authorEskiler, Gamze Güney
dc.contributor.authorBilir, Filiz
dc.date.accessioned2022-12-08T09:15:59Z
dc.date.available2022-12-08T09:15:59Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Chlorine dioxide (ClO2) is an effective disinfectant consisting of oxygen, chloride, and potassium. Because of its high oxidative capacity, ClO2 exerts antimicrobial, antiviral, and antifungal effects. However, its anticancer effects remain to be elucidated. Methodology The anticancer activity of ClO2 was assessed on DMS114 small-cell lung cancer (SCLC) cells and human umbilical vein endothelial cells (HUVEC) as control by WST-1, Annexin V, cell cycle analysis, and acridine orange staining. We for the first time investigated the possible therapeutic effects of long-term stabilized ClO2 solution (LTSCD). Results Our preliminary findings showed that LTSCD significantly inhibited the proliferation of SCLC cells (p < 0.01) with less toxicity in HUVEC cells. Additionally, LTSCD induced apoptotic cell death in SCLC cells through nuclear blehhing and vacuolar formation. However, LTSCD treatment did not induce cell cycle arrest in both cell lines. Conclusions LTSCD can be a therapeutic potential for the treatment of SCLC. However, further investigations are required to assess the LTSCD-induced cell death in SCLC both in vitro and in vivo.en_US
dc.identifier.citationYıldız, S. Z., Bilir, C., Eskiler, G. G., & Bilir, F. (2022). The Anticancer Potential of Chlorine Dioxide in Small-Cell Lung Cancer Cells. Cureus, 14(10).en_US
dc.identifier.doi10.7759/cureus.29989en_US
dc.identifier.issn2168-8184en_US
dc.identifier.issue10en_US
dc.identifier.urihttp://dx.doi.org/10.7759/cureus.29989
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3437
dc.identifier.volume14en_US
dc.identifier.wosWOS:000877509600032en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBilir, Cemil
dc.language.isoenen_US
dc.publisherCUREUS INCen_US
dc.relation.ispartofCUREUS JOURNAL OF MEDICAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSmall-Cell Lung Canceren_US
dc.subjectAnticanceren_US
dc.subjectDms114 Cell Lineen_US
dc.subjectApoptosisen_US
dc.subjectChlorine Dioxideen_US
dc.titleThe anticancer potential of chlorine dioxide in small-cell lung cancer cellsen_US
dc.typeArticleen_US

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