Dextran-coated iron oxide nanoparticles in combination with ginger extract without NGF promote neurite outgrowth and PC12 cell branching

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dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridEsmaeili, Abolghasem/0000-0002-8844-4591
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosidEsmaeili, Abolghasem/S-9320-2018
dc.contributor.authorSadeghi, Sanaz
dc.contributor.authorEsmaeili, Abolghasem
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2024-05-19T14:41:51Z
dc.date.available2024-05-19T14:41:51Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractNeurogenesis is decreased in the absence of nerve growth factor (NGF). It would be beneficial to discover substances that stimulate neurogenesis without NGF, given the high molecular weight and brief half-life of NGF. This work aims to assess the neurogenesis of ginger extract (GE) combined with superparamagnetic iron oxide nanoparticles (SPIONs) without NGF. Based on our research, GE and SPIONs start neurogenesis before NGF. In comparison to the control group, GE and SPIONs dramatically reduced the length and quantity of neurites, according to statistical analysis. Our findings also indicated that SPIONs and ginger extract together had an additive impact on one another. The total number significantly increased with the addition of GE and nanoparticles. In comparison to NGF, the mixture of GE and nanoparticles significantly enhanced the total number of cells with neurites (by about 1.2-fold), the number of branching points (by about 1.8-fold), and the length of neurites. The difference between ginger extract and nanoparticles with NGF was significant (about 3.5-fold), particularly in the case of cells with one neurite. The results of this study point to the possibility of treating neurodegenerative disorders via the combination of GE and SPIONs without NGF.en_US
dc.identifier.doi10.1016/j.envres.2023.116302
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.pmid37286125en_US
dc.identifier.scopus2-s2.0-85161279412en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.envres.2023.116302
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5168
dc.identifier.volume232en_US
dc.identifier.wosWOS:001017702200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofEnvironmental Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectGingeren_US
dc.subjectIron Nanoparticlesen_US
dc.subjectPc-12 Cellen_US
dc.subjectNeuritogenesisen_US
dc.titleDextran-coated iron oxide nanoparticles in combination with ginger extract without NGF promote neurite outgrowth and PC12 cell branchingen_US
dc.typeArticleen_US

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