Mesoporous bioactive glasses in cancer diagnosis and therapy: stimuli-responsive, toxicity, immunogenicity, and clinical translation

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorSharifi, Esmaeel
dc.contributor.authorBigham, Ashkan
dc.contributor.authorYousefiasl, Satar
dc.contributor.authorTrovato Maria
dc.contributor.authorGhomi, Matineh
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2021-11-22T11:38:33Z
dc.date.available2021-11-22T11:38:33Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractCancer is one of the top life-threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy-to-functionalize nature and tailorable textural properties-surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy ( particularly, targeted delivery and stimuli-responsive nanoplatforms), and immunological profile of MBG-based nanodevices in reference to the development of novel cancer therapeutics.en_US
dc.identifier.citationSharifi, E., Bigham, A., Yousefiasl, S., Trovato, M., Ghomi, M., Esmaeili, Y., Samadi, P., Zarrabi, A., Ashrafizadeh, M., Sharifi, S., Sartorius, R., Dabbagh Moghaddam, F., Maleki, A., Song, H., Agarwal, T., Maiti, T. K., Nikfarjam, N., Burvill, C., Mattoli, V., Raucci, M. G., … Makvandi, P. (2021). Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli-Responsive, Toxicity, Immunogenicity, and Clinical Translation. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e2102678. Advance online publication.en_US
dc.identifier.doi10.1002/advs.202102678en_US
dc.identifier.pmid34796680en_US
dc.identifier.scopus2-s2.0-85119376936en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/advs.202102678
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2266
dc.identifier.wosWOS:000720283400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAdvanced Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCancer Therapyen_US
dc.subjectDiagnosisen_US
dc.subjectGene and Drug Deliveryen_US
dc.subjectImmunotherapyen_US
dc.subjectMesoporous Bioactive Glassesen_US
dc.subjectToxicological Profileen_US
dc.titleMesoporous bioactive glasses in cancer diagnosis and therapy: stimuli-responsive, toxicity, immunogenicity, and clinical translationen_US
dc.typeReview Articleen_US

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