Chitosan/collagen composite films as wound dressings encapsulating allantoin and lidocaine hydrochloride

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridZeynep Püren Akgüner / 0000-0002-9626-1605en_US
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorscopusidZeynep Püren Akgüner / 57205403842
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.authorwosidZeynep Püren Akgüner / CBX-7589-2022
dc.contributor.authorYaşayan, Gökçen
dc.contributor.authorKaraca, Gizem
dc.contributor.authorPüren Akgüner, Zeynep
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2020-08-30T20:06:13Z
dc.date.available2020-08-30T20:06:13Z
dc.date.issued2020
dc.departmentSağlık Bilimleri Enstitüsü, Kök Hücre ve Doku Mühendisliği Ana Bilim Dalıen_US
dc.description.abstractChitosan/collagen composite scaffolds encapsulating allantoin and lidocaine hydrochloride were formulated in various ratios and characterized in vitro for their applications in wound healing. After fabrication, scaffolds were characterized in terms of topographical properties, surface roughness, and swelling behavior, and then their stabilities were monitored by hydrolytic and enzymatic degradation studies. Following compatibility studies among the active ingredients, drugs were encapsulated within scaffolds, and encapsulation efficiency and drug release studies were carried. Finally, in vitro cell viability and scratch wound healing assays were carried to assess scaffolds as wound dressings. Results suggest that blending of polymers with drugs changed topographical properties and surface roughness prominently. It is found that the formulation with chitosan/collagen ratio of 70/30 is more resistant to both hydrolytic and enzymatic degradation routes due to having favored properties of both collagen and chitosan. In vitro drug release studies indicated rapid release of drugs, hence the scaffolds could be advantageous for patients that need an immediate anesthetic effect in wound healing therapy. The cell culture studies demonstrated that the chitosan/collagen composite scaffolds showed no toxicity, and cell migrations were increased depending on the collagen ratio in scaffolds. These results suggest that chitosan/collagen scaffolds combined with allantoin and lidocaine hydrochloride could be a promising candidate for wound healing applications.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Coordination UnitMarmara University [SAG-CYLP-070317-0091]en_US
dc.description.sponsorshipThis work has been supported by Marmara University Scientific Research Projects Coordination Unit under Grant [number SAG-CYLP-070317-0091].en_US
dc.identifier.citationYaşayan, G., Karaca, G., Akgüner, Z. P., & Bal Öztürk, A. (2020). Chitosan/collagen composite films as wound dressings encapsulating allantoin and lidocaine hydrochloride. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-13.en_US
dc.identifier.doi10.1080/00914037.2020.1740993en_US
dc.identifier.issn0091-4037en_US
dc.identifier.issn1563-535Xen_US
dc.identifier.scopus2-s2.0-85082458670en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00914037.2020.1740993
dc.identifier.urihttps://hdl.handle.net/20.500.12713/429
dc.identifier.wosWOS:000524010200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorPüren Akgüner, Zeynepen_US
dc.institutionauthorBal Öztürk, Ayçaen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Asen_US
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllantoinen_US
dc.subjectChitosanen_US
dc.subjectCollagenen_US
dc.subjectLidocaine Hydrochlorideen_US
dc.subjectWound Dressingen_US
dc.titleChitosan/collagen composite films as wound dressings encapsulating allantoin and lidocaine hydrochlorideen_US
dc.typeArticleen_US

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