Thermoreversible Gel Formulation for the Intranasal Delivery of Salmon Calcitonin and Comparison Studies of In Vivo Bioavailability

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dc.authoridyıldız türkyılmaz, gülbeyaz/0000-0002-8601-0263
dc.authorwosidyıldız türkyılmaz, gülbeyaz/AAF-7766-2019
dc.contributor.authorAlparslan, Abdullah Levent
dc.contributor.authorTurkyilmaz, Guelbeyaz Yildiz
dc.contributor.authorKozaci, Leyla Didem
dc.contributor.authorKarasulu, Ercuement
dc.date.accessioned2024-05-19T14:46:34Z
dc.date.available2024-05-19T14:46:34Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: We developed original thermoreversible (sol-gel) formulations of salmon calcitonin (sCT) for nasal applications. The sol-gel has been compared with commercial intranasal sprays in vitro and in vivo studies. The aim of studying sol-gel form is to arrange the viscosity of formulations for a reversible adequate fluidity at different temperatures. This situation may facilitate the use of drugs as sprays and increase the bioadhesive ability to mucosa. Materials and Methods: Characterization of optimum formulations was studied. Validated analytical assays determined the number of sCT. An approximately equal number of commercial and sol-gel dosages were sprayed into the nostrils of the rabbits. Blood samples were collected from the ear veins of rabbits and determined by enzyme immunoassay plates. These plates were evaluated by Thermo Labsystem Multiscan Spectrum at 450 nm. Thanks to Winnonlin 5.2, pharmacokinetic data were evaluated by a non-compartmental method. Results: The absolute bioavailability of the formulation at pH 4 and the commercial product (CP) was compared by evaluating the primary pharmacokinetic data area under the curve 0 & RARR;tlast. The absolute bioavailability of the commercial intranasal spray was measured 1.88 based on maximum concentration (Cmax) assessment. Cmax of the sol-gel formulation pH 4 was calculated as 0.99 and the relative bioavailability was obtained 53.3%. Conclusion: In vivo pharmacokinetic data of sol-gel formulation with pH 3 showed significantly higher volume of distribution parameter than the CP (111167>35408). It is thought that the formulation adhered to the nasal mucosa releases sCT slowly and less.en_US
dc.identifier.doi10.4274/tjps.galenos.2022.09482
dc.identifier.endpage140en_US
dc.identifier.issn1304-530X
dc.identifier.issn2148-6247
dc.identifier.issue3en_US
dc.identifier.pmid37416996en_US
dc.identifier.scopus2-s2.0-85165139626en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage127en_US
dc.identifier.trdizinid1189382en_US
dc.identifier.urihttps://doi.org10.4274/tjps.galenos.2022.09482
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1189382
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5550
dc.identifier.volume20en_US
dc.identifier.wosWOS:001041092600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectSalmon Calcitoninen_US
dc.subjectThermoreversible Gelen_US
dc.subjectSol-Gelen_US
dc.subjectBioavailabilityen_US
dc.subjectNasal Sprayen_US
dc.titleThermoreversible Gel Formulation for the Intranasal Delivery of Salmon Calcitonin and Comparison Studies of In Vivo Bioavailabilityen_US
dc.typeArticleen_US

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