DNA damage response inhibitors in cholangiocarcinoma: current progress and perspectives
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PubMed
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and its incidence is dramatically increasing. The lack of understanding of the biology of this tumor has slowed down the identification of novel targets and the development of effective treatments. Based on next generation sequencing profiling, alterations in DNA damage response (DDR)-related genes are paving the way for DDR-targeting strategies in CCA. Based on the notion of synthetic lethality, several DDR-inhibitors (DDRi) have been developed with the aim of accumulating enough DNA damage to induce cell death in tumor cells. Observing that DDRi alone could be insufficient for clinical use in CCA patients, the combination of DNA-damaging regimens with targeted approaches has started to be considered, as evidenced by many emerging clinical trials. Hence, novel therapeutic strategies combining DDRi with patient-specific targeted drugs could be the next level for treating cholangiocarcinoma.
Açıklama
Anahtar Kelimeler
Biliary Tract Cancer, Targeted Therapy, DNA Damage, Synthetic Lethality, PARP, Wee1
Kaynak
Cells
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
11
Sayı
9
Künye
Gönül Geyik Ö, Anichini G, Ulukaya E, Marra F, Raggi C. DNA Damage Response Inhibitors in Cholangiocarcinoma: Current Progress and Perspectives. Cells. 2022 Apr 26;11(9):1463. doi: 10.3390/cells11091463. PMID: 35563769; PMCID: PMC9101358.
