Increased levels of serum IL-33 is associated with adverse maternal outcomes in placenta previa accreta

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dc.authoridBaşak Gümüş Güler / 0000-0002-0182-6774
dc.authorscopusidBaşak Gümüş Güler / 57193546825
dc.authorwosidBaşak Gümüş Güler / JHA-5039-2023
dc.date.accessioned2020-08-30T20:06:30Z
dc.date.available2020-08-30T20:06:30Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstractPurpose: IL-33 is associated with invasion, proliferation, and metastasis of various cancers. The trophoblastic cells of placenta previa accreta (PPA) invade into the myometrium in a similar way to the invasion of cancers. We studied the role of IL-33 in PPA and also aimed to investigate its relation with adverse maternal outcome in this placental disorder. Methods: A total of 87 pregnant patients were enrolled in this prospective case-control study [27 with PPA, 30 with placenta previa totalis (PPT; nonadherent placenta previa), and 30 controls]. IL-33 and IL-6 levels were studied in maternal serum at late preterm gestation weeks. Multiple logistic regression analyses analyzed the risk factors which are associated with PPA and adverse maternal outcomes. Adjusted odds ratios and 95% confidence intervals were also calculated. Enzyme-linked immunosorbent assay (ELISA) method was used to determine maternal serum IL-33 and IL-6 levels. Results: Serum IL-33 levels were significantly higher in PPA patients when compared with both nonadherent PPT and the control groups (p = .011, p = .010). Serum IL-6 and neutrophil/lymphocyte ratio levels were significantly higher than the control group's (p = .045, p = .028). IL-33 levels and history of previous cesarean section were found to be significantly associated with PPA (OR: 1.039, 95% CI: 1.004-1.075; p = .030 and OR: 0.067, 95% CI: 0.014-0.309, p = .001, respectively). Serum IL-33 levels were positively correlated with previous cesarean section history in PPA. Increased maternal serum IL-33 levels were found to be independently associated with a cesarean hysterectomy and massive transfusion in PPA patients (OR: 1.098, 95% CI: 0.998-1.207; p = .049 and OR: 1.162 95% CI: 1.010-1.337; p = .036). Conclusion: Increased levels of maternal serum IL-33 and history of previous cesarean section were found to be significantly associated with PPA, and also increased maternal serum IL-33 levels were related to cesarean hysterectomy and massive blood transfusion in PPA. We suggest that IL-33 may have a role in abnormal placental invasion.en_US
dc.identifier.citationOzler, S., Oztas, E., Guler, B. G., & Caglar, A. T. (2019). Increased levels of serum IL-33 is associated with adverse maternal outcomes in placenta previa accreta. The Journal of Maternal-Fetal & Neonatal Medicine, 1-8.en_US
dc.identifier.doi10.1080/14767058.2019.1679766en_US
dc.identifier.issn1476-7058en_US
dc.identifier.issn1476-4954en_US
dc.identifier.pmid31608786en_US
dc.identifier.scopus2-s2.0-85074505244en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2019.1679766
dc.identifier.urihttps://hdl.handle.net/20.500.12713/535
dc.identifier.wosWOS:000492097600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGümüş Güler, Başaken_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCesarean Hysterectomyen_US
dc.subjectInterleukin 33en_US
dc.subjectInterleukin 6en_US
dc.subjectMassive Blood Transfusionen_US
dc.subjectNonadherent Placenta Previa Totalisen_US
dc.subjectPlacenta Previa Accretaen_US
dc.titleIncreased levels of serum IL-33 is associated with adverse maternal outcomes in placenta previa accretaen_US
dc.typeArticleen_US

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