Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility

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dc.authoridMuammer Kendirci / 0000-0002-1854-1871en_US
dc.authorscopusidMuammer Kendirci / 8625690500
dc.authorwosidMuammer Kendirci / AAA-3790-2019
dc.contributor.authorAgarwal, Ashok
dc.contributor.authorParekh, Neel
dc.contributor.authorSelvam, Manesh Kumar Panner
dc.contributor.authorHenkel, Ralf
dc.contributor.authorShah, Rupin
dc.contributor.authorHoma, Sheryl T.
dc.contributor.authorHarlev, Avi
dc.date.accessioned2020-08-30T20:06:38Z
dc.date.available2020-08-30T20:06:38Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractDespite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.en_US
dc.description.sponsorshipAmerican Center for Reproductive Medicineen_US
dc.description.sponsorshipFinancial support for this study was provided by the American Center for Reproductive Medicine.en_US
dc.identifier.citationAgarwal, A., Parekh, N., Panner Selvam, M. K., Henkel, R., Shah, R., Homa, S. T., ... & Majzoub, A. (2019). Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility. The world journal of men's health, 37(3), 296-312.en_US
dc.identifier.doi10.5534/wjmh.190055en_US
dc.identifier.endpage312en_US
dc.identifier.issn2287-4208en_US
dc.identifier.issn2287-4690en_US
dc.identifier.issue3en_US
dc.identifier.pmid31081299en_US
dc.identifier.scopus2-s2.0-85073335150en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage296en_US
dc.identifier.urihttps://doi.org/10.5534/wjmh.190055
dc.identifier.urihttps://hdl.handle.net/20.500.12713/578
dc.identifier.volume37en_US
dc.identifier.wosWOS:000482196700006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKendirci, Muammeren_US
dc.language.isoenen_US
dc.publisherKorean Soc Sexual Medicine & Andrologyen_US
dc.relation.ispartofWorld Journal of Mens Healthen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfertility, Maleen_US
dc.subjectMosien_US
dc.subjectOxidation Reduction Potentialen_US
dc.subjectOxidative Stressen_US
dc.subjectSemenen_US
dc.titleMale oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertilityen_US
dc.typeReview Articleen_US

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