The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism

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dc.authoridBaşak Gümüş Güler / 0000-0002-0182-6774
dc.authorscopusidBaşak Gümüş Güler / 57193546825
dc.authorwosidBaşak Gümüş Güler / JHA-5039-2023
dc.contributor.authorÖzler, Sibel
dc.contributor.authorBostancı, E. İşci
dc.contributor.authorÖztaş, E.
dc.contributor.authorPekcan, M. Kuru
dc.contributor.authorGümüş Güler, Başak
dc.contributor.authorYılmaz, N.
dc.date.accessioned2020-08-30T20:07:15Z
dc.date.available2020-08-30T20:07:15Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstractWe aimed to determine the relation of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4), and a disintegrin and metalloproteinase with thrombospondin motifs-9 (ADAMTS9) with cardiovascular disease (CVD) risk, in ovarian dysfunction patients with premature ovarian insufficiency (POI), and idiopathic hypogonadotropic hypogonadism (IHH). 43 IHH and 44 POI patients were enrolled to this case-control study. Serum hormonal parameters, lipid profiles, ADAMTS4 and ADAMTS9 levels were measured. Lipid accumulation product (LAP) index, visceral adiposity index (VAI), and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. The patients with at least two out of the four following criteria were accepted to have increased CVD risk; waist-to-hip ratio (WHR) ae<yen> 0.8, waist circumference (WC) ae<yen> 79 cm, triglycerides (TG) ae<yen> 150 mg/dL, high-density lipoprotein cholesterol (HDL-C) < 50 mg/dL. Serum ADAMTS4 and ADAMTS9 levels were measured by enzyme-linked immunosorbent assay (ELISA). ADAMTS4 and ADAMTS9 levels were significantly higher in the IHH group than the POI group (p = 0.002, and p = 0.013, respectively). IHH group had significantly higher levels of insulin, HOMA-IR index, and LAP index (p = 0.006, p = 0.005, and p = 0.013, respectively). The mean age of patients in the IHH group (23.60 +/- 5.64 years) was significantly lower than the POI group (31.05 +/- 6.03 years), (p < 0.001). Odds ratios (OR) were 1.236 (95% CI 1.055-1.447) and 1.002 (95% CI 1.000-1.004) for LAP index and ADAMTS4, respectively, in the IHH group. These two parameters found to have high predictivity for CVD risk in the IHH group (p = 0.009 and p = 0.028, respectively). The lower levels of ADAMTS4 in the POI group, when compared with the IHH patients pointed out that even limited hormone secretion and ovulation in the POI group, may have protective effect on cardiovascular system. The higher levels of ADAMTS4 and LAP index in the IHH group demonstrated the increased risk of these patients for CVD.en_US
dc.identifier.citationOzler, S., Bostanci, E. I., Oztas, E., Pekcan, M. K., Guler, B. G., & Yilmaz, N. (2018). The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism. Journal of endocrinological investigation, 41(12), 1477-1483.en_US
dc.identifier.doi10.1007/s40618-018-0948-3en_US
dc.identifier.endpage1483en_US
dc.identifier.issn1720-8386en_US
dc.identifier.issue12en_US
dc.identifier.pmid30187439en_US
dc.identifier.scopus2-s2.0-85052927366en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1477en_US
dc.identifier.urihttps://doi.org/10.1007/s40618-018-0948-3
dc.identifier.urihttps://hdl.handle.net/20.500.12713/725
dc.identifier.volume41en_US
dc.identifier.wosWOS:000451294600014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGümüş Güler, Başaken_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdamts4en_US
dc.subjectAdamts9en_US
dc.subjectPremature Ovarian Insufficiencyen_US
dc.subjectIdiopathic Hypogonadotropic Hypogonadismen_US
dc.subjectLap Indexen_US
dc.subjectCardiovascular Disease Risken_US
dc.titleThe role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadismen_US
dc.typeArticleen_US

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