Are thyroid functions affected in multisystem inflammatory syndrome in children?

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dc.authoridGönül Çatlı / 0000-0002-0488-6377en_US
dc.authorscopusidGönül Çatlı / 35783928000
dc.authorwosidGönül Çatlı / AGX-8645-2022en_US
dc.contributor.authorElvan-Tuz, Ayşegül
dc.contributor.authorAyrancı, İlkay
dc.contributor.authorEkemen-Keleş, Yıldız
dc.contributor.authorKarakoyun, İnanç
dc.contributor.authorÇatlı, Gönül
dc.contributor.authorKara-Aksay, Ahu
dc.contributor.authorKaradağ-Öncel, Eda
dc.contributor.authorDündar, Bumin Nuri
dc.contributor.authorYilmaz, Dilek
dc.date.accessioned2022-07-25T13:35:49Z
dc.date.available2022-07-25T13:35:49Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is defined as the presence of documented fever, inflammation, and at least two signs of multisystem involvement and lack of an alternative microbial diagnosis in children who have recent or current SARS-CoV-2 infection or exposure. In this study, we evaluated thyroid function tests in pediatric cases with MIS-C in order to understand how the hypothalamus-pituitary-thyroid axis is affected and to examine the relationship between disease severity and thyroid functions. Material and methods: This case-control study was conducted in our clinic between January 2021 and September 2021. The patient group consisted of 36 MIS-C cases, the control group included 72 healthy children. Demographic features, clinical findings, inflammatory markers, thyroid function tests, and thyroid antibody levels of MIS-C cases were recorded. Thyroid function tests were recorded in the healthy control group. Results: When MIS-C and healthy control groups were compared in terms of thyroid hormones, free triiodothyronine (FT3) level was lower in MIS-C cases, while free thyroxine (FT4) level was found to be lower in the healthy group (p=<0.001, p=0.001, respectively). Although the FT4 level was statistically significantly lower in the healthy group, no significant difference was found compared with the reference intervals according to age (p=0.318). When compared to the MIS-C cases without intensive care requirement, FT3 levels were also lower in MIS-C cases admitted to the intensive care unit and received steroid treatment (p=0.043, p=<0.001, respectively). Discussion: In conclusion, since the endocrinological system critically coordinates and regulates important metabolic and biochemical pathways, examination of this system may be beneficial for MIS-C. In our study, low FT3 levels were associated with both the diagnosis of MIS-C and severe clinical presentation. Further studies are needed to predict the prognosis and develop a long-term follow-up management plan.en_US
dc.identifier.citationElvan-Tuz A, Ayranci I, Ekemen-Keles Y, Karakoyun I, Catli G, Kara-Aksay A, Karadag-Oncel E, Dundar BN, Yilmaz D. Are Thyroid Functions Affected in Multisystem Inflammatory Syndrome in Children? J Clin Res Pediatr Endocrinol. 2022 Jun 30. doi: 10.4274/jcrpe.galenos.2022.2022-4-7. Epub ahead of print. PMID: 35770945.en_US
dc.identifier.doi10.4274/jcrpe.galenos.2022.2022-4-7en_US
dc.identifier.issn1308-5727en_US
dc.identifier.pmid35770945en_US
dc.identifier.scopus2-s2.0-85143180127en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.trdizinid1173361en_US
dc.identifier.urihttp://doi.org/10.4274/jcrpe.galenos.2022.2022-4-7
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3038
dc.identifier.wosWOS:000908310600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇatlı, Gönül
dc.language.isoenen_US
dc.publisherGalenos Publication Systemen_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMIS-Cen_US
dc.subjectFree Thyroxineen_US
dc.subjectThyroid Functionen_US
dc.subjectFree Triiodothyronineen_US
dc.titleAre thyroid functions affected in multisystem inflammatory syndrome in children?en_US
dc.typeArticleen_US

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