Radiosensitization with metallic nanoparticles under MeV proton beams: local dose enhancement
Yükleniyor...
Dosyalar
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer science and business media deutschland GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In addition to specific dosimetric properties of protons, their higher biological effectiveness makes them superior to X-rays and gamma radiation, in radiation therapy. In recent years, enrichment of tumours with metallic nanoparticles as radiosensitizer agents has generated high interest, with several studies attempting to confirm the efficacy of nanoparticles in proton therapy. In the present study Geant4 Monte Carlo (MC) code was used to quantify the increased nanoscopic dose deposition of 50 nm metallic nanoparticles including gold, bismuth, iridium, and gadolinium in water upon exposure to 5, 25, and 50 MeV protons. Dose enhancement factors, radial dose distributions in nano-scale, as well as secondary electron and photon energy spectra were calculated for the studied nanoparticles and proton beams. The obtained results demonstrated that in the presence of metallic nanoparticles an increase in proton energy leads to a decrease in secondary electron and photon production yield. Additionally, an increase in the radial dose enhancement factor from 1.4 to 16 was calculated for the studied nanoparticles when the proton energy was increased from 5 to 50 MeV. It is concluded that the dosimetric advantages of proton beams could be improved significantly in the presence of metallic nanoparticles.
Açıklama
Anahtar Kelimeler
Dose Enhancement, Geant4, Metallic Nanoparticle, Proton Therapy
Kaynak
Radiation and environmental biophysics
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
63
Sayı
4
Künye
Mansouri, E., Almisned, G., Tekin, H. O., Rajabpour, S., & Mesbahi, A. (2024). Radiosensitization with metallic nanoparticles under MeV proton beams: Local dose enhancement. Radiation and Environmental Biophysics, 1-7.
