Radiosensitization with metallic nanoparticles under MeV proton beams: local dose enhancement

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dc.authorscopusidHüseyin Ozan Tekin / 56971130700
dc.authorwosidHüseyin Ozan Tekin / J-9611-2016
dc.contributor.authorMansouri, Elham
dc.contributor.authorAlmisned, Ghada
dc.contributor.authorTekin, Hüseyin Ozan
dc.contributor.authorRajabpour, Saeed
dc.contributor.authorMesbahi, Asghar
dc.date.accessioned2025-04-18T09:57:10Z
dc.date.available2025-04-18T09:57:10Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractIn addition to specific dosimetric properties of protons, their higher biological effectiveness makes them superior to X-rays and gamma radiation, in radiation therapy. In recent years, enrichment of tumours with metallic nanoparticles as radiosensitizer agents has generated high interest, with several studies attempting to confirm the efficacy of nanoparticles in proton therapy. In the present study Geant4 Monte Carlo (MC) code was used to quantify the increased nanoscopic dose deposition of 50 nm metallic nanoparticles including gold, bismuth, iridium, and gadolinium in water upon exposure to 5, 25, and 50 MeV protons. Dose enhancement factors, radial dose distributions in nano-scale, as well as secondary electron and photon energy spectra were calculated for the studied nanoparticles and proton beams. The obtained results demonstrated that in the presence of metallic nanoparticles an increase in proton energy leads to a decrease in secondary electron and photon production yield. Additionally, an increase in the radial dose enhancement factor from 1.4 to 16 was calculated for the studied nanoparticles when the proton energy was increased from 5 to 50 MeV. It is concluded that the dosimetric advantages of proton beams could be improved significantly in the presence of metallic nanoparticles.
dc.description.sponsorshipPrincess Nourah Bint Abdulrahman University Princess Nourah Bint Abdulrahman University
dc.identifier.citationMansouri, E., Almisned, G., Tekin, H. O., Rajabpour, S., & Mesbahi, A. (2024). Radiosensitization with metallic nanoparticles under MeV proton beams: Local dose enhancement. Radiation and Environmental Biophysics, 1-7.
dc.identifier.doi10.1007/s00411-024-01090-3
dc.identifier.endpage543
dc.identifier.issn0301634X
dc.identifier.issue4
dc.identifier.pmid39150514
dc.identifier.scopus2-s2.0-85201421273
dc.identifier.scopusqualityQ2
dc.identifier.startpage537
dc.identifier.urihttp://dx.doi.org/10.1007/s00411-024-01090-3
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6899
dc.identifier.volume63
dc.identifier.wosWOS:001292652000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTekin, Hüseyin Ozan
dc.institutionauthoridHüseyin Ozan Tekin / 0000-0002-0997-3488
dc.language.isoen
dc.publisherSpringer science and business media deutschland GmbH
dc.relation.ispartofRadiation and environmental biophysics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDose Enhancement
dc.subjectGeant4
dc.subjectMetallic Nanoparticle
dc.subjectProton Therapy
dc.titleRadiosensitization with metallic nanoparticles under MeV proton beams: local dose enhancement
dc.typeArticle

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