Ruxolitinib salvage therapy is effective for steroid-refractory graft-versus-host disease in children: a single-center experience
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background Despite the increasing performance of allogeneic hematopoietic cell transplantation over the last decades, graft-versus-host disease (GVHD) remains the main cause of morbidity and mortality. The efficacy of ruxolitinib against GVHD has been demonstrated in adult studies; however, very few studies have been conducted in children. Procedure This study aimed to evaluate the efficacy of ruxolitinib in 29 children with steroid-refractory acute or chronic GVHD. Twenty-five (87%) patients received at least three different immune modulator agents, including methylprednisolone, before initiating ruxolitinib. Results All grade 2 acute GVHD patients completely responded to ruxolitinib treatment; 82% of high-grade (3-4) acute GVHD patients and 80% of chronic GVHD (moderate-severe) patients had at least a partial response. Of seven patients with bronchiolitis obliterans, five had a partial response after ruxolitinib. Of 29 patients, 22 were administered steroids at any time in the first month of acute GVHD or the first three months of chronic GVHD during ruxolitinib usage, which was significantly tapered by the end of the observation period. Conclusion Steroid-refractory acute and chronic pediatric GVHD patients treated with ruxolitinib had a high overall response rate, with the additional benefit of steroid sparing.
Açıklama
KILIC, SUAR CAKI/0000-0001-7489-2054; Hazar, Volkan/0000-0002-1407-2334
Uygun, Vedat ; Karasu, Gulsun Tezcan (isu author)
Uygun, Vedat ; Karasu, Gulsun Tezcan (isu author)
Anahtar Kelimeler
Children, Gvhd, Ruxolitinib, Transplantation
Kaynak
Pediatric Blood & Cancer
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
67
Sayı
4
Künye
Uygun, V., Karasu, G., Daloglu, H., Ozturkmen, S., Kilic, S. C., Yalcin, K., … Yesilipek, A. (2020). Ruxolitinib salvage therapy is effective for steroid-refractory graft-versus-host disease in children: A single-center experience. PEDIATRIC BLOOD & CANCER, 67(4). https://doi.org/10.1002/pbc.28190
