Ruxolitinib salvage therapy is effective for steroid-refractory graft-versus-host disease in children: a single-center experience

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dc.authoridVedat Uygun / 0000-0003-3257-7798
dc.authoridGülsün Tezcan Karasu / 0000-0001-5700-5919
dc.authorscopusidVedat Uygun / 10043117000
dc.authorscopusidGülsün Tezcan Karasu / 56382958800
dc.authorwosidVedat Uygun / AGH-4534-2022
dc.authorwosidGülsün Tezcan Karasu / IAF-9902-2023
dc.contributor.authorUygun, Vedat
dc.contributor.authorTezcan Karasu, Gülsün
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorÖztürkmen, Seda
dc.contributor.authorKılıç, Suar Çakı
dc.contributor.authorYalçın, Koray
dc.contributor.authorÇelen, Safiye Suna
dc.contributor.authorHazar, Volkan
dc.contributor.authorYeşilipek, Akif
dc.date.accessioned2020-08-30T20:06:17Z
dc.date.available2020-08-30T20:06:17Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKILIC, SUAR CAKI/0000-0001-7489-2054; Hazar, Volkan/0000-0002-1407-2334en_US
dc.descriptionUygun, Vedat ; Karasu, Gulsun Tezcan (isu author)
dc.description.abstractBackground Despite the increasing performance of allogeneic hematopoietic cell transplantation over the last decades, graft-versus-host disease (GVHD) remains the main cause of morbidity and mortality. The efficacy of ruxolitinib against GVHD has been demonstrated in adult studies; however, very few studies have been conducted in children. Procedure This study aimed to evaluate the efficacy of ruxolitinib in 29 children with steroid-refractory acute or chronic GVHD. Twenty-five (87%) patients received at least three different immune modulator agents, including methylprednisolone, before initiating ruxolitinib. Results All grade 2 acute GVHD patients completely responded to ruxolitinib treatment; 82% of high-grade (3-4) acute GVHD patients and 80% of chronic GVHD (moderate-severe) patients had at least a partial response. Of seven patients with bronchiolitis obliterans, five had a partial response after ruxolitinib. Of 29 patients, 22 were administered steroids at any time in the first month of acute GVHD or the first three months of chronic GVHD during ruxolitinib usage, which was significantly tapered by the end of the observation period. Conclusion Steroid-refractory acute and chronic pediatric GVHD patients treated with ruxolitinib had a high overall response rate, with the additional benefit of steroid sparing.en_US
dc.identifier.citationUygun, V., Karasu, G., Daloglu, H., Ozturkmen, S., Kilic, S. C., Yalcin, K., … Yesilipek, A. (2020). Ruxolitinib salvage therapy is effective for steroid-refractory graft-versus-host disease in children: A single-center experience. PEDIATRIC BLOOD & CANCER, 67(4). https://doi.org/10.1002/pbc.28190en_US
dc.identifier.doi10.1002/pbc.28190en_US
dc.identifier.issn1545-5009en_US
dc.identifier.issn1545-5017en_US
dc.identifier.issue4en_US
dc.identifier.pmid31981413en_US
dc.identifier.scopus2-s2.0-85078809871en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/pbc.28190
dc.identifier.urihttps://hdl.handle.net/20.500.12713/459
dc.identifier.volume67en_US
dc.identifier.wosWOS:000509125100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUygun, Vedaten_US
dc.institutionauthorTezcan Karasu, Gülsünen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Blood & Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectGvhden_US
dc.subjectRuxolitiniben_US
dc.subjectTransplantationen_US
dc.titleRuxolitinib salvage therapy is effective for steroid-refractory graft-versus-host disease in children: a single-center experienceen_US
dc.typeArticleen_US

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