The effect of LDHs nanoparticles on the cellular behavior of stem cell-laden 3D-bioprinted scaffold

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridBurçin İzbudak / 0000-0002-5572-7966
dc.authorscopusidBurçin İzbudak / 57221779519
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorwosidAyça Bal Öztürk / M-4472-2018en_US
dc.authorwosidBurçin Özbudak / GXP-7807-2022
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2022-06-08T12:04:32Z
dc.date.available2022-06-08T12:04:32Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractThree-dimensional (3D)-bioprinting as an emerging approach for tissue engineering possesses the promise to create highly mimicked organs or tissues by using computer-aided design. For biomedical applications in tissue engineering in our previous work, we developed an optimized nanocomposite bioink based on methylacrylated gelatin (GeIMA), methylacrylated chitosan (ChitMA), and double-layered hydroxide (LDHs) nanoparticles by using 3D-bioprinting technology. Herein, we used the previous formulation to fabricate human bone marrow mesenchymal stem cells (hBMMSCs)-laden nanocomposite bioinks. The effect of LDHs nanoparticles on the cellular behaviors of the encapsulated-hBMMSCs in the scaffolds was evaluated for the first time. Live/Dead, PrestoBlue, and DAPI/Actin analysis were carried out to assess the cell viability, proliferation rate, and cellular morphology of encapsulated hBMMSCs within the scaffolds. In addition, osteogenic differentiation studies were performed culturing the scaffolds for up to 21 days. Results show that LDHs nanoparticles in the GeIMA/ChitMA scaffold formulation increased the viability of hBMMSCs, did not cause any adverse effect on the proliferation rate, cell morphology of the hBMMSCs, and increased the Runx2 protein expression of the encapsulated-hBMMSCs in the scaffolds. This study progresses the LDHs containing nanocomposite bioink for cell printing applications in tissue engineering.en_US
dc.identifier.citationIzbudak, B., Bal-Ozturk, A. (2022). The effect of LDHs nanoparticles on the cellular behavior of stem cell-laden 3D-bioprinted scaffold. Journal of Biomaterials Applications.en_US
dc.identifier.doi10.1177/08853282221082921en_US
dc.identifier.issn0885-3282en_US
dc.identifier.scopus2-s2.0-85130036415en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1177/08853282221082921
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2837
dc.identifier.wosWOS:000786606000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorİzbudak, Burçin
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONSen_US
dc.relation.ispartofJOURNAL OF BIOMATERIALS APPLICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioinken_US
dc.subjectThree-Dimensional-Bioprintingen_US
dc.subjectCell Ladenen_US
dc.subjectDouble-Layered Hydroxideen_US
dc.subjectNanocompositeen_US
dc.titleThe effect of LDHs nanoparticles on the cellular behavior of stem cell-laden 3D-bioprinted scaffolden_US
dc.typeArticleen_US

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