Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity
Yükleniyor...
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACG Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Herein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-propyl]pyrimidine-2,4-(1 H,3H ) dione (6) (67% yield) is described. After successful microwave synthesis steps, MTT cytotoxicity experiments gave rise to greater cytotoxic effect of compound 6 in MCF-7 human breast adenocarcinoma cell line (IC50= 1.35 µM) as compared to literature values for tamoxifen (IC50= 8.3 µM) and doxorubicin (IC50= 27 µM).
Açıklama
Anahtar Kelimeler
1-(3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-prop-1-yl)pyrimidine-2,4(1 H,3H)-dione, Microwave synthesis, NMR; IC50, Phenothiazine Derivatives
Kaynak
Organic Communications
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
13
Sayı
4
Künye
Andac, C. A. Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity.
