Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity

Yükleniyor...
Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

ACG Publications

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Herein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-propyl]pyrimidine-2,4-(1 H,3H ) dione (6) (67% yield) is described. After successful microwave synthesis steps, MTT cytotoxicity experiments gave rise to greater cytotoxic effect of compound 6 in MCF-7 human breast adenocarcinoma cell line (IC50= 1.35 µM) as compared to literature values for tamoxifen (IC50= 8.3 µM) and doxorubicin (IC50= 27 µM).

Açıklama

Anahtar Kelimeler

1-(3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-prop-1-yl)pyrimidine-2,4(1 H,3H)-dione, Microwave synthesis, NMR; IC50, Phenothiazine Derivatives

Kaynak

Organic Communications

WoS Q Değeri

N/A

Scopus Q Değeri

Q4

Cilt

13

Sayı

4

Künye

Andac, C. A. Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity.