Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity

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dc.authoridAhmet Cenk Andaç / 0000-0002-4545-3500en_US
dc.authorscopusidAhmet Cenk Andaç / 20336962400
dc.authorwosidAhmet Cenk Andaç / AAW-5539-2020
dc.contributor.authorAndaç, Ahmet Cenk
dc.date.accessioned2021-01-12T10:11:11Z
dc.date.available2021-01-12T10:11:11Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractHerein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-propyl]pyrimidine-2,4-(1 H,3H ) dione (6) (67% yield) is described. After successful microwave synthesis steps, MTT cytotoxicity experiments gave rise to greater cytotoxic effect of compound 6 in MCF-7 human breast adenocarcinoma cell line (IC50= 1.35 µM) as compared to literature values for tamoxifen (IC50= 8.3 µM) and doxorubicin (IC50= 27 µM).en_US
dc.identifier.citationAndac, C. A. Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity.en_US
dc.identifier.doi10.25135/acg.oc.86.20.10.1853en_US
dc.identifier.endpage183en_US
dc.identifier.issn1307-6175en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85098686290en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage175en_US
dc.identifier.trdizinid416696en_US
dc.identifier.urihttps://www.doi.org/10.25135/acg.oc.86.20.10.1853
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1312
dc.identifier.volume13en_US
dc.identifier.wosWOS:000604128100004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorAndaç, Ahmet Cenk
dc.language.isoenen_US
dc.publisherACG Publicationsen_US
dc.relation.ispartofOrganic Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject1-(3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-prop-1-yl)pyrimidine-2,4(1 H,3H)-dioneen_US
dc.subjectMicrowave synthesisen_US
dc.subjectNMR; IC50en_US
dc.subjectPhenothiazine Derivativesen_US
dc.titleFacile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activityen_US
dc.typeArticleen_US

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