A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells

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dc.authoridRemzi Okan Akar / 0000-0001-8687-2034en_US
dc.authoridDidem Karakaş Zeybek / 0000-0002-3781-6834en_US
dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidRemzi Okan Akar / 57210603359
dc.authorscopusidDidem Karakaş Zeybek / 56422040600
dc.authorwosidDidem Karakaş Zeybek / CAF-9974-2022en_US
dc.authorwosidRemzi Okan Akar / AAF-4576-2019en_US
dc.authorwosidEngin Ulukaya / K-5792-2018en_US
dc.contributor.authorKarakaş Zeybek, Didem
dc.contributor.authorAkar, Remzi Okan
dc.contributor.authorGökmen, Zeliha
dc.contributor.authorUlukaya, Engin
dc.contributor.authorDeniz, Nahide Gülsah
dc.date.accessioned2022-06-13T13:53:57Z
dc.date.available2022-06-13T13:53:57Z
dc.date.issued2019en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAbstract: Breast cancer is the most-diagnosed cancer type among women. The triple-negative subtype is an especially aggressive type of breast cancer. Although chemotherapy is almost the only option for the treatment of triple-negative breast cancer (TNBC), currently used chemotherapeutics are not effective enough, considering the poor survival rate of patients. Therefore, novel compounds need to be developed to improve survival rates. It has been known that quinonic compounds, which are found in nature, have antibacterial, antifungal, and antitumorigenic properties. Naphthoquinones are members of the quinone family and are widely used in research due to their promising properties. In this study, we evaluated the cytotoxic activity of a novel naphthoquinone-derived compound (1,4-naphthoquinone (1,4-NQ)) against two different breast cancer cells: a hormone-responsive cell line (MCF-7) and a triple-negative cell line (MDA-MB-231). As a result, 1,4-NQ decreased cell viability in both tested cell lines in a dose-dependent manner. Increased apoptotic markers (presence of pyknotic nuclei, annexin-V positivity, caspase 3/7 activity, and decreased mitochondrial membrane potential) and DNA damage were especially observed in MDA-MB-231 cells after treatment with the compound. Considering the promising cytotoxic effect of the compound, 1,4-NQ needs further evaluation as a potential candidate for the treatment of TNBC.en_US
dc.identifier.citationKARAKAŞ D,AKAR R. O,GÖKMEN Z,DENİZ N. G,ULUKAYA E (2019). A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells. Turkish Journal of Biology, 43(4), 256 - 263. Doi: 10.3906/biy-1901-19en_US
dc.identifier.doi10.3906/biy-1901-19en_US
dc.identifier.endpage263en_US
dc.identifier.issn1300-0152en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85073301962en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage256en_US
dc.identifier.trdizinid336244en_US
dc.identifier.urihttp://doi.org/10.3906/biy-1901-19
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2886
dc.identifier.volume43en_US
dc.identifier.wosWOS:000478814000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlukaya, Engin
dc.institutionauthorAkar, Remzi Okan
dc.institutionauthorKarakaş Zeybek, Didem
dc.language.isoenen_US
dc.publisherTR- Dizinen_US
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectQuinonesen_US
dc.subjectCytotoxicityen_US
dc.subjectApoptosisen_US
dc.subjectTriple-Negative Breast Canceren_US
dc.subjectAnticancer Agenten_US
dc.subject1,4-naphthoquinonesen_US
dc.titleA novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cellsen_US
dc.typeArticleen_US

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