Castleman disease: a multicenter case series from Turkey

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dc.authoridTülin Tiraje Celkan / 0000-0001-7287-1276
dc.authorscopusidTülin Tiraje Celkan / 35584411200
dc.authorwosidTülin Tiraje Celkan / FZB-3980-2022
dc.contributor.authorGunduz, Eren
dc.contributor.authorKirkizlar, Hakki Onur
dc.contributor.authorUmit, Elif Gulsum
dc.contributor.authorKaraman Gulsaran, Sedanur
dc.contributor.authorOzkocaman, Vildan
dc.contributor.authorCelkan, Tülin Tiraje
dc.date.accessioned2022-02-21T06:22:38Z
dc.date.available2022-02-21T06:22:38Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Castleman disease (CD) is a rare disease also known as angiofollicular lymph node hyperplasia. Two main histological subtypes are hyaline vascular and plasma cell variant. It is classified as unicentric (UCD) or multicentric CD (MCD) according to the anatomical distribution of disease and the number of lymph nodes involved. The aim of this multicenter study is to evaluate all cases of CD identified to date in Turkey to set up a national registry aiming to improve CD early recognition, treatment and follow-up. Materials and methods: Both adult (n=130) and pediatric (n=10) patients with a lymph node or involved field biopsy result reported as CD were included in the study. Patients' demographic information, clinical and laboratory characteristics, imaging studies, treatment strategies and clinical outcome were evaluated retrospectively. Results: 140 patients (69 male and 71 female) with a diagnosis of UCD (n = 73) and MCD (n = 67) were included. Mean age was 39 in UCD and 47 in MCD. Female patients were more common in UCD. The most common histologic subtype was hyaline vascular for both UCD and MCD. Asymptomatic patients were more common in UCD. Anemia, elevation of acute phase reactants and hypoalbuminemia were more common in MCD. Most commonly used treatment strategies in UCD were surgical excision, rituximab and radiotherapy respectively. All UCD patients were alive at a median 19.5 month follow up. Most commonly used treatment strategies in MCD were methyl prednisolone, R-CHOP, R-CVP and rituximab. Thirteen patients died at a median 34 month follow up. Conclusion: Our study is important due to representing the patient characteristics and treatment strategies from Turkey and have a potential of increasing awareness about CD. Treatment data may help making decision particularly in countries who can not get access to siltuximab. Larger prospective studies are needed to make definitive conclusions.en_US
dc.identifier.citationGündüz E, Kırkızlar HO, Ümit EG, Karaman Gülsaran S, Özkocaman V, Özkalemkaş F, Candar Ö, Elverdi T, Küçükyurt S, Paydaş S, Ceneli Ö, Karakuş S, Maral S, Ekinci Ö, İpek Y, Kis C, Güven ZT, Akdeniz A, Celkan T, Eroğlu Küçükdiler AH, Akgün Çağlıyan G, Özçelik Şengöz C, Karataş A, Bulduk T, Özcan A, Belen Apak FB, Canbolat A, Kartal İ, Ören H, Töret E, Özdemir GN, Bakanay Öztürk ŞM. Castleman Disease: A Multicenter Case Series from Turkey. Turk J Haematol. 2022 Feb 18.en_US
dc.identifier.doi10.4274/tjh.galenos.2022.2021.0670en_US
dc.identifier.pmid35176839en_US
dc.identifier.scopus2-s2.0-85131226359en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.trdizinid515131en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2022.2021.0670
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2495
dc.identifier.wosWOS:000810203000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCelkan, Tülin Tiraje
dc.language.isoenen_US
dc.relation.ispartofTurk J Haematolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCastleman Diseaseen_US
dc.subjectMulticentricen_US
dc.subjectTreatmenten_US
dc.subjectUnicentricen_US
dc.titleCastleman disease: a multicenter case series from Turkeyen_US
dc.title.alternativeCastleman hastalığı: Türkiye’den çok merkezli bir olgu serisien_US
dc.typeArticleen_US

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