Embryonic aortic arch material properties obtained by optical coherence tomography-guided micropipette aspiration

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dc.authoridGürsan Çoban / 0000-0001-8057-8408en_US
dc.authorscopusidGürsan Çoban / 26421561000en_US
dc.authorwosidGürsan Çoban / DXM-5619-2022en_US
dc.contributor.authorLashkarinia, S.Samaneh
dc.contributor.authorÇoban, Gürsan
dc.contributor.authorBanu Siddiqui, Hummaira
dc.contributor.authorHwai Yap, Choon
dc.contributor.authorPekkan, Kerem
dc.date.accessioned2022-12-19T07:20:37Z
dc.date.available2022-12-19T07:20:37Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Yazılım Mühendisliği Bölümüen_US
dc.description.abstractIt is challenging to determine the in vivo material properties of a very soft, mesoscale arterial vesselsof size ? 80 to 120 ?m diameter. This information is essential to understand the early embryonic cardiovascular development featuring rapidly evolving dynamic microstructure. Previous research efforts to describe the properties of the embryonic great vessels are very limited. Our objective is to measure the local material properties of pharyngeal aortic arch tissue of the chick-embryo during the early Hamburger-Hamilton (HH) stages, HH18 and HH24. Integrating the micropipette aspiration technique with optical coherence tomography (OCT) imaging, a clear vision of the aspirated arch geometry is achieved for an inner pipette radius of Rp = 25 ?m. The aspiration of this region is performed through a calibrated negatively pressurized micro-pipette. A computational finite element model is developed to model the nonlinear behaviour of the arch structure by considering the geometry-dependent constraints. Numerical estimations of the nonlinear material parameters for aortic arch samples are presented. The exponential material nonlinearity parameter (a) of aortic arch tissue increases statistically significantly from a = 0.068 ± 0.013 at HH18 to a = 0.260 ± 0.014 at HH24 (p = 0.0286). As such, the aspirated tissue length decreases from 53 ?m at HH18 to 34 ?m at HH24. The calculated NeoHookean shear modulus increases from 51 Pa at HH18 to 93 Pa at HH24 which indicates a statistically significant stiffness increase. These changes are due to the dynamic changes of collagen and elastin content in the media layer of the vessel during development. © 2022 Elsevier Ltden_US
dc.identifier.citationLashkarinia, S. S., Coban, G., Siddiqui, H. B., Yap, C. H., & Pekkan, K. (2022). Embryonic aortic arch material properties obtained by optical coherence tomography-guided micropipette aspiration. Journal of Biomechanics, 111392.en_US
dc.identifier.doi10.1016/j.jbiomech.2022.111392en_US
dc.identifier.isbn00219290
dc.identifier.scopus2-s2.0-85143541405en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jbiomech.2022.111392
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3610
dc.identifier.volume146en_US
dc.identifier.wosWOS:000991404600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇoban, Gürsan
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Biomechanicsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiaxial Testingen_US
dc.subjectChick Embryoen_US
dc.subjectFinite Elementen_US
dc.subjectHyperelastic Modelsen_US
dc.subjectMechanical Contacten_US
dc.subjectMechanotransductionen_US
dc.subjectPharyngeal Aortic Archen_US
dc.subjectPipette Aspirationen_US
dc.subjectSoft Tissueen_US
dc.titleEmbryonic aortic arch material properties obtained by optical coherence tomography-guided micropipette aspirationen_US
dc.typeArticleen_US

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