Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Bloodstream, Gram-Negative, Health Care, Colistin Mic
Kaynak
Journal of Hospital Infection
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
98
Sayı
3
Künye
Aydin, M., Ergonul, O., Azap, A., Bilgin, H., Aydin, G., Cavus, S. A., … Stud, H.-R. I. (2018). Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections. JOURNAL OF HOSPITAL INFECTION, 98(3), 260–263. https://doi.org/10.1016/j.jhin.2017.11.014
