Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections

Yükleniyor...
Küçük Resim

Tarih

2018

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

W B Saunders Co Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Açıklama

Anahtar Kelimeler

Bloodstream, Gram-Negative, Health Care, Colistin Mic

Kaynak

Journal of Hospital Infection

WoS Q Değeri

Q1

Scopus Q Değeri

Q1

Cilt

98

Sayı

3

Künye

Aydin, M., Ergonul, O., Azap, A., Bilgin, H., Aydin, G., Cavus, S. A., … Stud, H.-R. I. (2018). Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections. JOURNAL OF HOSPITAL INFECTION, 98(3), 260–263. https://doi.org/10.1016/j.jhin.2017.11.014