Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections

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dc.authoridZehra Çağla Karakoç / 0000-0002-1618-740X
dc.authorscopusidZehra Çağla Karakoç / 54889818300
dc.authorwosidZehra Çağla Karakoç / AAR-5295-2020
dc.contributor.authorAydın, M.
dc.contributor.authorErgönül, O.
dc.contributor.authorAzap, A.
dc.contributor.authorBilgin, H.
dc.contributor.authorAydın, G.
dc.contributor.authorÇavuş, S. A.
dc.contributor.authorDemiroğlu, Y. Z.
dc.contributor.authorAlışkan, H. E.
dc.contributor.authorMemikoğlu, O.
dc.contributor.authorMenekşe, S.
dc.contributor.authorKaya, S.
dc.contributor.authorDemir, N. A.
dc.contributor.authorKaraoğlan, I.
dc.contributor.authorBaşaran, S.
dc.contributor.authorHatipoğlu, C.
dc.contributor.authorErdinç, S.
dc.contributor.authorYılmaz, E.
dc.contributor.authorTümtürk, A.
dc.contributor.authorTezer, Y.
dc.contributor.authorDemirkaya, H.
dc.contributor.authorÇakar, S. E.
dc.contributor.authorKeşke, S.
dc.contributor.authorTekin, S.
dc.contributor.authorYardımcı, C.
dc.contributor.authorKarakoç, Zehra Çağla
dc.contributor.authorErgen, P.
dc.contributor.authorAzap, O.
dc.contributor.authorMülazimoğlu, L.
dc.contributor.authorUral, O.
dc.contributor.authorCan, F.
dc.contributor.authorAkalın, H.
dc.date.accessioned2020-08-30T20:07:42Z
dc.date.available2020-08-30T20:07:42Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThis article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationAydin, M., Ergonul, O., Azap, A., Bilgin, H., Aydin, G., Cavus, S. A., … Stud, H.-R. I. (2018). Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections. JOURNAL OF HOSPITAL INFECTION, 98(3), 260–263. https://doi.org/10.1016/j.jhin.2017.11.014en_US
dc.identifier.doi10.1016/j.jhin.2017.11.014en_US
dc.identifier.endpage263en_US
dc.identifier.issn0195-6701en_US
dc.identifier.issn1532-2939en_US
dc.identifier.issue3en_US
dc.identifier.pmid29248504en_US
dc.identifier.scopus2-s2.0-85044363955en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage260en_US
dc.identifier.urihttps://doi.org/10.1016/j.jhin.2017.11.014
dc.identifier.urihttps://hdl.handle.net/20.500.12713/815
dc.identifier.volume98en_US
dc.identifier.wosWOS:000426316700011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarakoç, Zehra Çağlaen_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofJournal of Hospital Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBloodstreamen_US
dc.subjectGram-Negativeen_US
dc.subjectHealth Careen_US
dc.subjectColistin Micen_US
dc.titleRapid emergence of colistin resistance and its impact on fatality among healthcare-associated infectionsen_US
dc.typeArticleen_US

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