Laurus nobilis L. Essential Oil-Loaded PLGA as a Nanoformulation Candidate for Cancer Treatment

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dc.authoridTuğba Aydın / 0000-0002-8501-6217en_US
dc.authorscopusidTuğba Aydın / 57547547300en_US
dc.authorwosidTuğba Aydın / ABE-2525-2020
dc.contributor.authorErcin, Esin
dc.contributor.authorKecel-Gündüz, Serda
dc.contributor.authorGök, Bahar
dc.contributor.authorAydın, Tuğba
dc.contributor.authorBudama-Kılınç, Yasemin
dc.contributor.authorKartal, Murat
dc.date.accessioned2022-04-06T05:38:05Z
dc.date.available2022-04-06T05:38:05Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study was to obtain essential oil (LNEO) from the Laurus nobilis L. plant, and to prepare LNEO-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) as an approach in cancer treatment. The components of the obtained LNEO were analyzed using GC-MS. The LNEO-NPs were synthesized by the single-emulsion method. The LNEO-NPs were charac-terized using UV-Vis spectrometry, Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), and a DNA binding assay, which was performed via the UV-Vis titration method. According to the results, the LNEO-NPs had a 211.4 ± 4.031 nm average particle size, 0.068 ± 0.016 PdI, and ?7.87 ± 1.15 mV zeta potential. The encapsulation efficiency and loading capacity were calculated as 59.25% and 25.65%, respectively, and the in vitro drug release study showed an LNEO release of 93.97 ± 3.78% over the 72 h period. Moreover, the LNEO was intercalatively bound to CT-DNA. In addition, the mechanism of action of LNEO on a dual PI3K/mTOR inhibitor was predicted, and its antiproliferative activity and mechanism were determined using molecular docking analysis. It was concluded that LNEO-loaded PLGA NPs may be used for cancer treatment as a novel phytotherapeutic agent-based controlled-release system. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.identifier.citationErcin, E., Kecel-Gunduz, S., Gok, B., Aydin, T., Budama-Kilinc, Y., & Kartal, M. (2022). Laurus nobilis L. Essential Oil-Loaded PLGA as a Nanoformulation Candidate for Cancer Treatment. Molecules, 27(6), 1899.en_US
dc.identifier.doi10.3390/molecules27061899en_US
dc.identifier.issn1420-3049en_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85127003021en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/molecules27061899
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2599
dc.identifier.volume27en_US
dc.identifier.wosWOS:000774665500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAydın, Tuğba
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectControlled Release Systemen_US
dc.subjectDNA Bindingen_US
dc.subjectLaurel Essential Oilen_US
dc.subjectNanoparticleen_US
dc.subjectPLGAen_US
dc.titleLaurus nobilis L. Essential Oil-Loaded PLGA as a Nanoformulation Candidate for Cancer Treatmenten_US
dc.typeArticleen_US

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