Neuroprotective effect of cinnamaldehyde on secondary brain injury after traumatic brain injury in a rat model

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dc.authoridBora Gürer / 0000-0003-1500-6184
dc.authorscopusidBora Gürer / 36448801100
dc.authorwosidBora Gürer / JIJ-1874-2023
dc.contributor.authorKuru Bektaşoğlu, Pınar
dc.contributor.authorKoyuncuoğlu, Türkan
dc.contributor.authorDemir, Dilan
dc.contributor.authorSucu, Gizem
dc.contributor.authorAkakın, Dilek
dc.contributor.authorPeker Eyüboğlu, İrem
dc.contributor.authorYüksel, Meral
dc.contributor.authorÇelikoğlu, Erhan
dc.contributor.authorYeğen, Berrak Ç.
dc.date.accessioned2021-08-02T07:08:15Z
dc.date.available2021-08-02T07:08:15Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The aim of this study was to investigate the possible neuroprotective effects of cinnamaldehyde (CA) on secondary brain injury after traumatic brain injury (TBI) in a rat model. Methods: Rats were randomly divided into 4 groups: control (n = 9), TBI (n = 9), vehicle (0.1% Tween 80; n = 8), and CA (100 mg/kg) (n = 9). TBI was induced by the weight-drop model. In brain tissues, myeloperoxidase activity and the levels of luminol-enhanced and lucigenin-enhanced chemiluminescence were measured. Interleukin 1?, interleukin 6, tumor necrosis factor ?, tumor growth factor ?, caspase-3, and cleaved caspase-3 were evaluated with an enzyme-linked immunosorbent assay method. Brain injury was histopathologically graded after hematoxylin-eosin staining. Y-maze and novel object recognition tests were performed before TBI and within 24 hours of TBI. Results: Higher myeloperoxidase activity levels in the TBI group (P < 0.001) were suppressed in the CA group (P < 0.05). Luminol-enhanced and lucigenin-enhanced chemiluminescence, which were increased in the TBI group (P < 0.001, for both), were decreased in the group that received CA treatment (P < 0.001 for both). Compared with the increased histologic damage scores in the cerebral cortex and dentate gyrus of the TBI group (P < 0.001), scores of the CA group were lower (P < 0.001). Decreased number of entries and spontaneous alternation percentage in the Y-maze test of the TBI group (P < 0.05 and P < 0.01, respectively) were not evident in the CA group. Conclusions: CA has shown neuroprotective effects by limiting neutrophil recruitment, suppressing reactive oxygen species and reducing histologic damage and acute hippocampal dysfunction.en_US
dc.identifier.citationBektaşoğlu, P. K., Koyuncuoğlu, T., Demir, D., Sucu, G., Akakın, D., Eyüboğlu, İ. P., ... & Gürer, B. (2021). Neuroprotective Effect of Cinnamaldehyde on The Secondary Brain Injury Seen After Traumatic Brain Injury in a Rat Model. World Neurosurgery.en_US
dc.identifier.doi10.1016/j.wneu.2021.06.117en_US
dc.identifier.issn1878-8750en_US
dc.identifier.pmid34224887en_US
dc.identifier.scopus2-s2.0-85110707326en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2021.06.117
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1970
dc.identifier.wosWOS:000687942800033en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGürer, Bora
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiinflammatoryen_US
dc.subjectAntioxidanten_US
dc.subjectCinnamaldehydeen_US
dc.subjectNeuroprotectionen_US
dc.subjectRaten_US
dc.subjectTraumatic Brain Injuryen_US
dc.titleNeuroprotective effect of cinnamaldehyde on secondary brain injury after traumatic brain injury in a rat modelen_US
dc.typeArticleen_US

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