The structural effects of vitamin a deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometrics

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dc.authoridİlknur Dursun / 0000-0001-7094-3336en_US
dc.authorscopusidİlknur Dursun / 15126492700
dc.authorwosidİlknur Dursun / AGW-2134-2022
dc.contributor.authorElibol, Birsen
dc.contributor.authorSevercan, Mete
dc.contributor.authorJakubowska-Doğru, Ewa
dc.contributor.authorDursun, İlknur
dc.contributor.authorSevercan, Feride
dc.date.accessioned2022-04-06T05:39:13Z
dc.date.available2022-04-06T05:39:13Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe structural effects of vitamin A-deficiency were examined on the molecular profiles of biomolecules of male rat hippocampus during prolonged ethanol intake/withdrawal using FT-IR spectroscopy coupled with chemometrics. Liquid ethanol diet with/without vitamin A was maintained to adult rats for 3-months. The rats were decapitated at different ethanol withdrawal times and FT-IR spectra were obtained. Ethanol consumption/withdrawal produced significant changes in proteins' conformations, whilst having insignificant structural effects on lipids. In vitamin A deficiency, ethanol produced structural changes in lipids by lipid ordering especially in the early-ethanol withdrawal. Furthermore, an increase in lipid and protein content, saturated/unsaturated lipid ratio, a decrease in nucleic acids content and decrease in membrane fluidity were observed. These changes were less severe in the presence of Vitamin A. This study is clinically important for individuals with vitamin A deficiency because they have to be more cautious when consuming alcohol to protect themselves from cognitive dysfunctions.en_US
dc.identifier.citationElibol, B., Severcan, M., Jakubowska-Dogru, E., Dursun, I., & Severcan, F. (2022). The structural effects of Vitamin A deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometrics. Journal of biophotonics, e202100377.en_US
dc.identifier.doi10.1002/jbio.202100377en_US
dc.identifier.pmid35333440en_US
dc.identifier.scopus2-s2.0-85127955675en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/jbio.202100377
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2603
dc.identifier.wosWOS:000780638400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDursun, İlknur
dc.language.isoenen_US
dc.relation.ispartofBiophotonicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEthanolen_US
dc.subjectFT-IR spectroscopyen_US
dc.subjectVitamin A deficiencyen_US
dc.subjectMale rat hippocampusen_US
dc.titleThe structural effects of vitamin a deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometricsen_US
dc.typeArticleen_US

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