Cinnamaldehyde has Antifibrotic Effects on Rats with Epidural Fibrosis

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dc.contributor.authorBektaşoğlu, P.K.
dc.contributor.authorSomay, A.
dc.contributor.authorHazneci, J.
dc.contributor.authorBorekci, A.
dc.contributor.authorGürer, B.
dc.date.accessioned2024-05-19T14:33:37Z
dc.date.available2024-05-19T14:33:37Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Laminectomy is a widely employed surgical procedure for the treatment of spinal stenosis, but it may lead to epidural fibrosis (EF) and failed back surgery syndrome. Cinnamaldehyde, a phenylpropanoid found in cinnamon, has demonstrated antioxidant and anti-inflammatory properties. In the present study, we hypothesized that topical application and systemic administration of cinnamaldehyde could be helpful in the prevention of EF in a rat laminectomy model. Methods: The rats were randomly assigned to control, local, and systemic Tween-80 and local and systemic cinnamaldehyde experimental groups (n = 6, per group). In the control group, just laminectomy was performed. In local treatment groups, applications were done just after the laminectomy onto dura. In systemic treatment groups, intraperitoneal administrations were performed following skin suturing. The degree of epidural fibrosis was evaluated macroscopically and histopathologically 4 weeks later. Results: Macroscopic assessment revealed decreased EF with both topical and systemic cinnamaldehyde application, whereas microscopic examination results were not significant. Conclusions: Our findings provide the first experimental evidence of cinnamaldehyde's potential protective effects against EF. © 2023 Elsevier Inc.en_US
dc.description.sponsorshipConflict of interest statement: The authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.en_US
dc.identifier.doi10.1016/j.wneu.2023.12.106
dc.identifier.endpagee400en_US
dc.identifier.issn1878-8750
dc.identifier.pmid38143035en_US
dc.identifier.scopus2-s2.0-85185509574en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpagee395en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2023.12.106
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4291
dc.identifier.volume183en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCinnamaldehydeen_US
dc.subjectEpidural Fibrosisen_US
dc.subjectLaminectomyen_US
dc.titleCinnamaldehyde has Antifibrotic Effects on Rats with Epidural Fibrosisen_US
dc.typeArticleen_US

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