Prediction of preterm delivery in threatened preterm labour with short cervical length

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020en_US
dc.contributor.authorHamzaoğlu, Kübra
dc.contributor.authorDavutoğlu Alıcı, Ebru
dc.contributor.authorBulut, Huri
dc.contributor.authorMadazlı, Rıza
dc.date.accessioned2022-05-31T05:41:19Z
dc.date.available2022-05-31T05:41:19Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIn this study, we evaluated the value of the uterocervical angle (UCA), myometrial thickness (MT), sICAM-1, sVCAM-1, soluble E-selectin (sE-selectin) and pentraxin 3 (PTX3) levels in women with threatened preterm labour (TPL) in predicting spontaneous preterm birth (sPTB) within 14 days in symptomatic women with cervical length (CL) measurements between 10 and 25 mm. Forty-six patients diagnosed with TPL, 47 healthy pregnant women were evaluated in a case-control study. sE-selectin (AUC = 0.744, p = .007) and PTX3 (AUC = 0.711, p = .019) were found to be effective in predicting preterm delivery within 14 days. In conclusion, maternal sE-selectin and PTX3 levels may be helpful in identifying pregnancies that will deliver within 14 days in symptomatic women with CL measurements between 10 and 25 mm. However, maternal sICAM-1 and sVCAM-1 levels, MT and UCA are not effective in the prediction of sPTB in TPL pregnancies. Impact StatementWhat is already known on this subject? Aetiology of spontaneous preterm birth (sPTB) is unclear and believed to be multifactorial, infection, inflammation, vascular endothelial dysfunction and uteroplacental ischaemia are all considered to be related to preterm delivery syndrome. Transvaginal cervical length (CL) measurement is a good indicator of increased risk of sPTB. Inflammation is accepted to have a central role in the process of labour.What do the results of this study add? soluble E-selectin (sE-selectin) and pentraxin 3 (PTX3) levels may be helpful in identifying pregnancies that will deliver within 14 days in symptomatic women with CL measurements between 10 and 25 mm.What are the implications of these findings for clinical practice and/or further research? This study will help understand the important role of the inflammatory process in predicting spontaneous preterm birth.en_US
dc.identifier.citationHamzaoğlu K, Alıcı Davutoğlu E, Bulut H, Madazli R. Prediction of preterm delivery in threatened preterm labour with short cervical length. J Obstet Gynaecol. 2022 May 23:1-6. doi: 10.1080/01443615.2022.2054680. Epub ahead of print. PMID: 35603552.en_US
dc.identifier.doi10.1080/01443615.2022.2054680en_US
dc.identifier.issn0144-3615en_US
dc.identifier.pmid35603552en_US
dc.identifier.scopus2-s2.0-85130907375en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttp://doi.org/10.1080/01443615.2022.2054680
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2751
dc.identifier.wosWOS:000800949000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofJOURNAL OF OBSTETRICS AND GYNAECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrediction Preterm Deliveryen_US
dc.subjectThreatened Preterm Labouren_US
dc.subjectCytokinesen_US
dc.subjectUterocervical Angleen_US
dc.subjectMyometrial Thicknessen_US
dc.titlePrediction of preterm delivery in threatened preterm labour with short cervical lengthen_US
dc.typeArticleen_US

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