Physiological parameters for prognosis in abdominal sepsis (PIPAS) study: a WSES observational study

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dc.authoridFatih Altıntoprak / 0000-0002-3939-8293
dc.authorscopusidFatih Altıntoprak / 35321108500
dc.authorwosidFatih Altıntoprak / EJS-3092-2022
dc.contributor.authorSartelli, Massimo
dc.contributor.authorAbu-Zidan, Fikri M.
dc.contributor.authorLabricciosa, Francesco M.
dc.contributor.authorKluger, Yoram
dc.contributor.authorCoccolini, Federico
dc.contributor.authorAnsaloni, Luca
dc.contributor.authorCatena, Fausto
dc.contributor.authorAltıntoprak, Fatih
dc.date.accessioned2020-08-30T20:06:41Z
dc.date.available2020-08-30T20:06:41Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackgroundTiming and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted.MethodsThis worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018.ResultsA total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate >= 22 breaths/min, systolic blood pressure < 100mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO(2)) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8.ConclusionsThe simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.en_US
dc.identifier.citationSartelli, M., Abu-Zidan, F. M., Labricciosa, F. M., Kluger, Y., Coccolini, F., Ansaloni, L., ... & Regimbeau, J. M. (2019). Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study. World journal of emergency surgery, 14(1), 34.en_US
dc.identifier.doi10.1186/s13017-019-0253-2en_US
dc.identifier.issn1749-7922en_US
dc.identifier.pmid31341511en_US
dc.identifier.scopus2-s2.0-85069147924en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13017-019-0253-2
dc.identifier.urihttps://hdl.handle.net/20.500.12713/592
dc.identifier.volume14en_US
dc.identifier.wosWOS:000475741400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAltıntoprak, Fatihen_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofWorld Journal of Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Peritonitisen_US
dc.subjectSource Controlen_US
dc.subjectEarly Warning Scoreen_US
dc.subjectEmergency Surgeryen_US
dc.titlePhysiological parameters for prognosis in abdominal sepsis (PIPAS) study: a WSES observational studyen_US
dc.typeArticleen_US

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