Overview of omics biomarkers in pituitary neuroendocrine tumors to design future diagnosis and treatment strategies

Basit Öğe Kaydı
dc.authoridAyşegül Çalışkan İşcan / 0000-0003-1887-9167en_US
dc.authorscopusidAyşegül Çalışkan İşcan / 57217079641
dc.authorwosidAyşegül Çalışkan İşcan / GNJ-6483-2022
dc.contributor.authorAydın, Büşra
dc.contributor.authorÇalışkan İşcan, Ayşegül
dc.contributor.authorArğa, Kazım Yalçın
dc.date.accessioned2021-07-05T12:42:40Z
dc.date.available2021-07-05T12:42:40Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractPituitary neuroendocrine tumors (PitNETs) are the second most common type of intracranial neoplasia. Since their manifestation usually causes hormone hypersecretion, effective management of PitNETs is indisputably necessary. Most of the non-functioning PitNETs pose a real challenge in diagnosis as they grow without giving any signs. Despite the good response of prolactinomas to dopamine agonist therapy, some of these tumors persist or recur; also, about 20% are resistant and 10% behave aggressively. The silent corticotropinomas may not cause symptoms until the tumor mass causes a complication. In somatotropinomas, the possibility of recurrence after transsphenoidal resection is more common in pediatric patients than in adult patients. Therefore, detection of tumors at early stages or identification of recurrence and remission after transsphenoidal surgery would allow wiser management of the disease. Extensive studies have been performed to uncover potential signatures that can be used for preventive diagnosis and/or prognosis of PitNETs as well as for targeted therapy. These molecular signatures at multiple biological levels hold promise for the convergence of preventive approaches and patient-centered disease management and offer potential therapeutic strategies. In this review, we provide an overview of the omics-based biomarker research and highlight the multi-omics signatures that have been proposed as pitNET biomarkers. In addition, understanding the multi-omics data integration of current biomarker discovery strategies was discussed in terms of preventive, predictive, and personalized medicine. The topics discussed in this review will help to develop broader visions for pitNET research, diagnosis, and therapy, particularly in the context of personalized medicine.en_US
dc.identifier.citationAydin, B., Caliskan, A., & Arga, K. Y. (2021). Overview of omics biomarkers in pituitary neuroendocrine tumors to design future diagnosis and treatment strategies. EPMA Journal, 1-19.en_US
dc.identifier.doi10.1007/s13167-021-00246-1en_US
dc.identifier.issn1878-5077en_US
dc.identifier.scopus2-s2.0-85108805821en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s13167-021-00246-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1878
dc.identifier.wosWOS:000666821500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇalışkan İşcan, Ayşegül
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofEPMA Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkersen_US
dc.subjectMulti-Omics Data Integrationen_US
dc.subjectOmics Biomarkersen_US
dc.subjectPituitary Adenomaen_US
dc.subjectPituitary Neuroendocrine Tumorsen_US
dc.subjectPredictive Preventive Personalized Medicineen_US
dc.titleOverview of omics biomarkers in pituitary neuroendocrine tumors to design future diagnosis and treatment strategiesen_US
dc.typeReview Articleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
94.pdf
Boyut:
1.95 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Eczacılık Temel Bilimleri Bölümü Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu