Microsatellite instability in ovarian invasive and borderline epithelial tumors and comparison with prognostic parameters

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dc.authoridSibel Şensu / 0000-0002-4607-780Xen_US
dc.authorscopusidSibel Şensu / 35746731800
dc.authorwosidSibel Şensu / AGU-9782-2022
dc.contributor.authorTürkel, Filiz İlhan
dc.contributor.authorGül, Aylin Ege
dc.contributor.authorŞensu, Sibel
dc.contributor.authorKeser, Sevinç Hallaç
dc.contributor.authorBarışık, Nagehan Özdemir
dc.date.accessioned2020-12-14T09:47:52Z
dc.date.available2020-12-14T09:47:52Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Ovarian cancers, 20% of which are hereditary, are considered the most lethal gynecological malignancies. Defects on DNA mismatch repair (MMR) genes are responsible for hereditary ovarian tumors related with Lynch syndrome. In this study, we aimed to determine microsatellite instability status in invasive and borderline epithelial ovarian tumors diagnosed via immunohistochemistry in our clinic and compare the results with several prognostic parameters and survival. Methods: In this retrospective study, 159 epithelial ovarian tumors were evaluated for age, tumor type, histological grade and Federation of Gynecology and Obstetrics (FIGO) stage as well as survival. MMR protein expression was immunohistochemically examined and absence of nuclear staining in tumor cells was considered MMR protein expression loss. All prognostic parameters were compared and analysed statistically. Results: MMR protein expression loss showed no statistically significant relationship with FIGO stage, age, histological grade, and survival. The only correlation was detected between tumor type and MMR protein loss (p<0.001). Conclusion: Although there are studies comparing microsatellite instability status of the tumors with several prognostic parameters, there is still no consensus on the issue. In this study on ovarian tumors, MMR protein expression loss was related with histological subtypes, but not with other prognostic parameters or survival. We believe that it is worth further investigating in larger studies with higher number of cases.en_US
dc.identifier.doi10.4274/haseki.galenos.2020.6125en_US
dc.identifier.endpage459en_US
dc.identifier.issn1302-0072en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85097127473en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage452en_US
dc.identifier.trdizinid427668en_US
dc.identifier.urihttps://www.doi.org/10.4274/haseki.galenos.2020.6125
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1272
dc.identifier.volume58en_US
dc.identifier.wosWOS:000595922200010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorŞensu, Sibel
dc.language.isoenen_US
dc.publisherGalenosen_US
dc.relation.ispartofHaseki Tip Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImmunohistochemistyen_US
dc.subjectMicrosatellite Instabilityen_US
dc.subjectMMR Expressionen_US
dc.subjectOvarian Tumorsen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.titleMicrosatellite instability in ovarian invasive and borderline epithelial tumors and comparison with prognostic parametersen_US
dc.title.alternativeOverin ınvazif ve borderline epitelyal tümörlerinde mikrosatellit ınstabilite ve prognostik parametreler ile karşılaştırılmasıen_US
dc.typeArticleen_US

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