Photo-crosslinkable chitosan and gelatin-based nanohybrid bioinks for extrusion-based 3D-bioprinting

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridBurçin İzbudak / 0000-0002-5572-7966
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorscopusidBurçin İzbudak / 57221779519
dc.authorwosidBurçin İzbudak / GXP-7807-2022
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.contributor.authorYüce Erarslan, Elif
dc.contributor.authorTutar, Rümeysa
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorAlarçin, Emine
dc.contributor.authorKocaağa, Banu
dc.contributor.authorGüner, F. Seniha
dc.contributor.authorEmik, Serkan
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2021-10-13T07:01:28Z
dc.date.available2021-10-13T07:01:28Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Enstitüsü, Kök Hücre ve Doku Mühendisliği Ana Bilim Dalıen_US
dc.description.abstractIn the last decade, 3D-bioprinting has attracted attention due to its capability to produce complex scaffolds. The selection of suitable biomaterials for the bioink design is very important for the success of 3D-bioprinting. In this study, chitosan and gelatin were chemically modified into methacrylated chitosan (ChiMA) and methacrylated gelatin (GelMA) with the methacrylic anhydride in order to obtain crosslinking points on the polymeric backbone. The eligible bioinks were formulated with the layered double hydroxide nanoparticles (LDHs). The effect of changing the amount of LDHs on the printability of the bioinks was evaluated by using rheological analysis and printability test with the extrusion-based 3D-bioprinting. The bioinks were crosslinked under UV light. Mechanical, swelling, degradation properties, and cell-adhesion behaviors of the obtained ChiMA/GelMA nanohybrid scaffolds containing LDHs were investigated. Based on the rheology and the printing results, ChiMA/GelMA nanohybrid scaffold containing 5% LDHs (ChiMA-G5) was found to be the optimal bioink. Notably, compression strength, elongation at break, and elastic modulus of ChiMA-G5 scaffold were higher than neat and other ChiMA/GelMA scaffolds. In vitro cell culture studies showed that LDHs do not have any negative effects. These findings indicate that the developed ChiMA-G5 bioink has great potential as a bioink to utilize for tissue engineering applications.en_US
dc.identifier.citationYuce-Erarslan, E., Tutar, R., İzbudak, B., Alarçin, E., Kocaaga, B., Guner, F. S., ... & Bal-Ozturk, A. (2021). Photo-crosslinkable chitosan and gelatin-based nanohybrid bioinks for extrusion-based 3D-bioprinting. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-12.en_US
dc.identifier.doi10.1080/00914037.2021.1981322en_US
dc.identifier.issn0091-4037en_US
dc.identifier.issn1563-535Xen_US
dc.identifier.scopus2-s2.0-85130014338en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00914037.2021.1981322
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2143
dc.identifier.wosWOS:000702971700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorİzbudak, Burçin
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS ASen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3D-Bioprintingen_US
dc.subjectLDHen_US
dc.subjectMethacrylated Chitosanen_US
dc.subjectMethacrylated Gelatinen_US
dc.subjectPhoto-Crosslinked Scaffoldsen_US
dc.subjectNanohybrid Bioinksen_US
dc.subjectNanoparticlesen_US
dc.titlePhoto-crosslinkable chitosan and gelatin-based nanohybrid bioinks for extrusion-based 3D-bioprintingen_US
dc.typeArticleen_US

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