Serum catestatin level is increased in women with preeclampsia

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorTüten, Nevin
dc.contributor.authorGüralp, Onur
dc.contributor.authorHamzaoğlu, Kübra
dc.contributor.authorÖner, Yahya Özgün
dc.contributor.authorMakul, Melike
dc.contributor.authorBulut, Huri
dc.contributor.authorIrmak Kübra
dc.contributor.authorTüten, Abdullah
dc.contributor.authorMalik, Eduard
dc.date.accessioned2021-05-05T09:06:45Z
dc.date.available2021-05-05T09:06:45Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractCatestatin can inhibit catecholamine release from chromaffin cells and adrenergic neurons. Catestatin can also have a strong vasodilator effect. This may be useful in understanding the pathophysiology of preeclampsia and its treatment. In this study, we investigated the serum catestatin levels in pregnant women with and without preeclampsia. Fifty consecutive women with mild preeclampsia, 50 consecutive women with severe preeclampsia, and 100 consecutive pregnant women with a gestational age-matched (±1 week) uncomplicated pregnancy were evaluated in a cross-sectional study. Mean serum catestatin was significantly increased in the preeclampsia group compared to the control group (290.7 ± 95.5 pg/mL vs. 182.8 ± 72.0 pg/mL). Mean serum catestatin was comparable in mild and severe preeclampsia groups (282.7 ± 97.9 pg/mL vs. 298.7 ± 93.4 pg/mL, p = .431). Serum catestatin levels had positive correlations with systolic and diastolic blood pressure, urea, uric acid, and creatinine. In conclusion, serum catestatin levels are increased in preeclamptic pregnancies compared to gestational age-matched controls.IMPACT STATEMENTWhat is already known on this subject? The role of autonomic nervous system dysregulation in the pathophysiology of preeclampsia is known. The most obvious part of this dysregulation is the sympathetic nervous system activation. The adrenal medulla is one of the locations of the sympathetic nervous system in the body.What do the results of this study add? Serum catestatin levels were found to be correlated with clinical and laboratory data of preeclampsia. This highlights the importance of chromaffin cell secretions in the adrenal medulla in preeclampsia.What are the implications of these findings for clinical practice and/or further research? This study will help understand the role of the adrenal medulla in the autonomic nervous system dysregulation in preeclampsia. Also, control of serum catestatin levels may support the treatment of hypertension in preeclampsia.en_US
dc.identifier.citationTüten, N., Güralp, O., Gök, K., Hamzaoglu, K., Oner, Y. O., Makul, M., Bulut, H., Irmak, K., Tüten, A., & Malik, E. (2021). Serum catestatin level is increased in women with preeclampsia. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 1–6. Advance online publication. https://doi.org/10.1080/01443615.2021.1873922en_US
dc.identifier.doi10.1080/01443615.2021.1873922en_US
dc.identifier.endpage7en_US
dc.identifier.pmid33938370en_US
dc.identifier.scopus2-s2.0-85105218598en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2021.1873922
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1725
dc.identifier.wosWOS:000646463100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherTaylor And Francisen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatecholaminesen_US
dc.subjectChromaffin Cellsen_US
dc.subjectChromogranin Aen_US
dc.subjectMild Preeclampsiaen_US
dc.subjectSevere Preeclampsiaen_US
dc.titleSerum catestatin level is increased in women with preeclampsiaen_US
dc.typeArticleen_US

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