Humoral and cellular immune response to SARS-CoV-2 mRNA BNT162b2 vaccine in pediatric kidney transplant recipients compared with dialysis patients and healthy children

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dc.authoridMehmet Taşdemir / 0000-0002-5579-6339en_US
dc.authorscopusidMehmet Taşdemir / 57188732568en_US
dc.authorwosidMehmet Taşdemir / HHX-0612-2022en_US
dc.contributor.authorGülmez, Rüveyda
dc.contributor.authorÖzbey, Doğukan
dc.contributor.authorAğbaş, Ayşe
dc.contributor.authorAksu, Bağdagül
dc.contributor.authorYıldız, Nurdan
dc.contributor.authorÜçkardeş, Diana
dc.contributor.authorTaşdemir, Mehmet
dc.date.accessioned2022-12-30T09:18:24Z
dc.date.available2022-12-30T09:18:24Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Compared with the general population, the immune response to COVID-19 mRNA vaccines is lower in adult kidney transplant recipients (KTRs). However, data is limited for pediatric KTRs. In this study, we aimed to assess humoral and cellular immune responses to the COVID-19 mRNA vaccine in pediatric KTRs. Methods: This multicenter, prospective, case-control study included 63 KTRs (37 male, aged 12-21 years), 19 dialysis patients, and 19 controls. Humoral (anti-SARS-CoV2 IgG, neutralizing Ab (nAb)) and cellular (interferon-gamma release assay (IGRA)) immune responses were assessed at least one month after two doses of BNT162b2 mRNA vaccine. Results: Among COVID-19 naïve KTRs (n = 46), 76.1% tested positive for anti-SARS-CoV-2 IgG, 54.3% for nAb, and 63% for IGRA. Serum levels of anti-SARS-CoV-2 IgG and nAb activity were significantly lower in KTRs compared to dialysis and control groups (p < 0.05 for all). Seropositivity in KTRs was independently associated with shorter transplant duration (p = 0.005), and higher eGFR (p = 0.007). IGRA titer was significantly lower than dialysis patients (p = 0.009). Twenty (43.4%) KTRs were positive for all immune parameters. Only four of 11 seronegative KTRs were IGRA-positive. COVID-19 recovered KTRs had significantly higher anti-SARS-CoV-2 IgG and nAb activity levels than COVID-19 naïve KTRs (p = 0.018 and p = 0.007, respectively). Conclusions: The humoral and cellular immune responses to SARS-CoV-2 mRNA BNT162b2 vaccine are lower in pediatric KTRs compared to dialysis patients. Further prospective studies are required to demonstrate the clinical efficacy of the mRNA vaccine in KTRs. This prospective study was registered in ClinicalTrials.gov (NCT05465863, registered retrospectively at 20.07.2022). A higher resolution version of the Graphical abstract is available as Supplementary information.en_US
dc.identifier.citationGulmez, R., Ozbey, D., Agbas, A., Aksu, B., Yildiz, N., Uckardes, D., Saygili, S., Yilmaz, E. K., Yildirim, Z. Y., Tasdemir, M., Kiykim, A., Cokugras, H., Canpolat, N., Nayir, A., Kocazeybek, B., & Caliskan, S. (2022). Humoral and cellular immune response to SARS-CoV-2 mRNA BNT162b2 vaccine in pediatric kidney transplant recipients compared with dialysis patients and healthy children. Pediatric nephrology (Berlin, Germany), 1–10. Advance online publication. https://doi.org/10.1007/s00467-022-05813-wen_US
dc.identifier.doi10.1007/s00467-022-05813-wen_US
dc.identifier.issn0931041Xen_US
dc.identifier.pmid36459243en_US
dc.identifier.scopus2-s2.0-85143241524en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://dx.doi.org/10.1007/s00467-022-05813-w
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3796
dc.identifier.wosWOS:000914635700006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaşdemir, Mehmet
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-SARS-CoV-2 IgGen_US
dc.subjectBNT162b2en_US
dc.subjectCOVID-19en_US
dc.subjectIGRAen_US
dc.subjectImmune Responseen_US
dc.subjectNeutralizing Antibodyen_US
dc.subjectmRNA Vaccineen_US
dc.titleHumoral and cellular immune response to SARS-CoV-2 mRNA BNT162b2 vaccine in pediatric kidney transplant recipients compared with dialysis patients and healthy childrenen_US
dc.typeArticleen_US

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