The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it's fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A population-based study showed that T. cruzi infection is associated with cognitive impairments. Therefore, if C. myxa has ameliorating activities on cognitive function, it would be useful for both T. cruzi infection and cognitive impairments. Methods: In this study, we evaluated the effects of an ethanol extract of leaves of C. myxa (ELCM) on memory impairments and sensorimotor gating deficits in mice. The phosphorylation level of protein was observed by the Western blot analysis. Results: The administration of ELCM significantly attenuated scopolamine-induced cognitive dysfunction in mice, as measured by passive avoidance test and novel object recognition test. Additionally, in the acoustic startle response test, we observed that the administration of ELCM ameliorated MK-801-induced prepulse inhibition deficits. We found that these behavioral outcomes were related with increased levels of phosphorylation phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3?) in the cortex and extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus by western blot analysis. Conclusions: These results suggest that ELCM would be a potential candidate for treating cognitive dysfunction and sensorimotor gating deficits observed in individuals with neurodegenerative diseases.
Açıklama
Anahtar Kelimeler
Alzheimer’s Disease, Cordia Myxa, ERK-CREB Signaling, PI3K-Akt-GSK3β Signalin, Recognition Memory, Sensorimotor Gating
Kaynak
BMC Complementary Medicine and Therapies
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
22
Sayı
1
Künye
Kendir G, Bae HJ, Kim J, Jeong Y, Bae HJ, Park K, Yang X, Cho YJ, Kim JY, Jung SY, Köroğlu A, Jang DS, Ryu JH. The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice. BMC Complement Med Ther. 2022 Aug 10;22(1):215. doi: 10.1186/s12906-022-03693-z. PMID: 35948926; PMCID: PMC9367120.
