The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice

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dc.authoridGülşen Kendir / 0000-0001-8879-3751en_US
dc.authorscopusidGülşen Kendir / 36088863100
dc.authorwosidGülşen Kendir / AFW-0019-2022en_US
dc.contributor.authorKendir, Gülşen
dc.contributor.authorJung Bae, Ho
dc.contributor.authorKim, Jihyun
dc.contributor.authorJeong, Yongwoo
dc.contributor.authorJeoung Bae, Hyo
dc.contributor.authorPark, Keontae
dc.contributor.authorYang, Xingquan
dc.contributor.authorCho, Young-Jin
dc.contributor.authorKim, Ji-Young
dc.contributor.authorJung, Seo Yun
dc.contributor.authorKoroglu, Aysegul
dc.contributor.authorJang, Dae Sik
dc.contributor.authorRyu, Jong Hoon
dc.date.accessioned2022-08-17T06:26:18Z
dc.date.available2022-08-17T06:26:18Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it's fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A population-based study showed that T. cruzi infection is associated with cognitive impairments. Therefore, if C. myxa has ameliorating activities on cognitive function, it would be useful for both T. cruzi infection and cognitive impairments. Methods: In this study, we evaluated the effects of an ethanol extract of leaves of C. myxa (ELCM) on memory impairments and sensorimotor gating deficits in mice. The phosphorylation level of protein was observed by the Western blot analysis. Results: The administration of ELCM significantly attenuated scopolamine-induced cognitive dysfunction in mice, as measured by passive avoidance test and novel object recognition test. Additionally, in the acoustic startle response test, we observed that the administration of ELCM ameliorated MK-801-induced prepulse inhibition deficits. We found that these behavioral outcomes were related with increased levels of phosphorylation phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3?) in the cortex and extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus by western blot analysis. Conclusions: These results suggest that ELCM would be a potential candidate for treating cognitive dysfunction and sensorimotor gating deficits observed in individuals with neurodegenerative diseases.en_US
dc.identifier.citationKendir G, Bae HJ, Kim J, Jeong Y, Bae HJ, Park K, Yang X, Cho YJ, Kim JY, Jung SY, Köroğlu A, Jang DS, Ryu JH. The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice. BMC Complement Med Ther. 2022 Aug 10;22(1):215. doi: 10.1186/s12906-022-03693-z. PMID: 35948926; PMCID: PMC9367120.en_US
dc.identifier.doi10.1186/s12906-022-03693-zen_US
dc.identifier.issn2662-7671en_US
dc.identifier.issue1en_US
dc.identifier.pmid9367120en_US
dc.identifier.scopus2-s2.0-85135773613en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1186/s12906-022-03693-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3096
dc.identifier.volume22en_US
dc.identifier.wosWOS:000838683000003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKendir, Gülşen
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBMC Complementary Medicine and Therapiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer’s Diseaseen_US
dc.subjectCordia Myxaen_US
dc.subjectERK-CREB Signalingen_US
dc.subjectPI3K-Akt-GSK3β Signalinen_US
dc.subjectRecognition Memoryen_US
dc.subjectSensorimotor Gatingen_US
dc.titleThe effects of the ethanol extract of Cordia myxa leaves on the cognitive function in miceen_US
dc.typeArticleen_US

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