Low ?-N-acetylgalactosaminidase plasma concentration correlates with the presence and severity of the bipolar affective disorder
Yükleniyor...
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: Believing that a neurodevelopmental pathology may cause bipolar affective disorder (BAD), we aimed to measure the concentrations of ?-N-acetylgalactosaminidase (?-NAGAL), a lysosomal enzyme. Methods: The study included 32 patients with BAD and 32 healthy controls. The Young Mania Rating Scale was used to measure the severity of the disease. Serum ?-N-acetylgalactosaminidase concentrations were measured in all blood samples using the human ?-N-acetylgalactosaminidase ELISA Kit. Results: A statistically significant difference was found in the ?-NAGAL values between the groups. The mean ?-NAGAL values of BAD patients are lower than the mean ?-NAGAL values of the control group. A strong negative and statistically significant relationship was found between the ?-NAGAL values of patients with BAD and their Young Mania Rating Scale scores. And a positive strong correlation was found between the age of onset of the disease and ?-NAGAL levels. Conclusions: Low ?-N-acetylgalactosaminidase concentrations may cause accumulation of some glycoproteins in the lysosomes in the brain during the gestational period, producing the clinical symptoms of BAD. ?-N-acetylgalactosaminidase deficiency may not be the only cause of BAD, but it may be an important factor in the etiology of this disease.
Açıklama
Anahtar Kelimeler
Bipolar Affective Disorder, Neurodevelopment, α-N-Acetylgalactosaminidase
Kaynak
The World Journal of Biological Psychiatry : The Official Journal of The World Federation of Societies of Biological Psychiatry
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
1
Sayı
11
Künye
Yılmaz S, Öner P. Low α-N-acetylgalactosaminidase plasma concentration correlates with the presence and severity of the bipolar affective disorder. World J Biol Psychiatry. 2022 Sep 14:1-11. doi: 10.1080/15622975.2022.2124451. Epub ahead of print. PMID: 36102137.
