Low ?-N-acetylgalactosaminidase plasma concentration correlates with the presence and severity of the bipolar affective disorder

Basit Öğe Kaydı
dc.authoridSeda Yılmaz / 0000-0001-5387-2345en_US
dc.authorscopusidSeda Yılmaz / 57728592500
dc.authorwosidSeda Yılmaz / HHJ-0276-2022en_US
dc.contributor.authorYılmaz, Seda
dc.contributor.authorÖner, Pinar
dc.date.accessioned2022-09-22T07:39:04Z
dc.date.available2022-09-22T07:39:04Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectives: Believing that a neurodevelopmental pathology may cause bipolar affective disorder (BAD), we aimed to measure the concentrations of ?-N-acetylgalactosaminidase (?-NAGAL), a lysosomal enzyme. Methods: The study included 32 patients with BAD and 32 healthy controls. The Young Mania Rating Scale was used to measure the severity of the disease. Serum ?-N-acetylgalactosaminidase concentrations were measured in all blood samples using the human ?-N-acetylgalactosaminidase ELISA Kit. Results: A statistically significant difference was found in the ?-NAGAL values between the groups. The mean ?-NAGAL values of BAD patients are lower than the mean ?-NAGAL values of the control group. A strong negative and statistically significant relationship was found between the ?-NAGAL values of patients with BAD and their Young Mania Rating Scale scores. And a positive strong correlation was found between the age of onset of the disease and ?-NAGAL levels. Conclusions: Low ?-N-acetylgalactosaminidase concentrations may cause accumulation of some glycoproteins in the lysosomes in the brain during the gestational period, producing the clinical symptoms of BAD. ?-N-acetylgalactosaminidase deficiency may not be the only cause of BAD, but it may be an important factor in the etiology of this disease.en_US
dc.identifier.citationYılmaz S, Öner P. Low α-N-acetylgalactosaminidase plasma concentration correlates with the presence and severity of the bipolar affective disorder. World J Biol Psychiatry. 2022 Sep 14:1-11. doi: 10.1080/15622975.2022.2124451. Epub ahead of print. PMID: 36102137.en_US
dc.identifier.doi10.1080/15622975.2022.2124451en_US
dc.identifier.issn1562-2975en_US
dc.identifier.issue11en_US
dc.identifier.pmid36102137en_US
dc.identifier.scopus2-s2.0-85139122573en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1080/15622975.2022.2124451
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3177
dc.identifier.volume1en_US
dc.identifier.wosWOS:000860538200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Seda
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofThe World Journal of Biological Psychiatry : The Official Journal of The World Federation of Societies of Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Affective Disorderen_US
dc.subjectNeurodevelopmenten_US
dc.subjectα-N-Acetylgalactosaminidaseen_US
dc.titleLow ?-N-acetylgalactosaminidase plasma concentration correlates with the presence and severity of the bipolar affective disorderen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Low N acetylgalactosaminidase plasma concentration correlates with the presence and severity of the bipolar affective disorder.pdf
Boyut:
720.93 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
İSÜ Hastaneleri Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu