Does the FT3-to-FT4 ratio easily predict the progression of NAFLD and NASH cirrhosis?
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Journals
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Factors causing progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH) and liver cirrhosis remain relatively unknown. We aimed to evaluate the power and effectiveness of the free triiodothyronine (FT3)-to-free thyroxine (FT4) ratio to predict non-alcoholic fatty liver disease (NAFLD)/liver fibrosis and NASH cirrhosis severity. Methods: Patients (n = 436) with NASH-associated liver cirrhosis (n = 68), patients with liver biopsy-proven NAFLD (n = 226), or healthy participants (n = 142) were enrolled between January 2010 and January 2020. The aspartate aminotransferase-to-thrombocyte ratio (APRI), NAFLD fibrosis score, albumin-bilirubin score (ALBI), aspartate aminotransferase (AST)-to-alanine aminotransferase (ALT) ratio, FT3-to-FT4 ratio, and Fibrosis-4 (FIB-4) were calculated and evaluated. Results: All parameters were significantly higher in NASH cirrhosis than in the healthy group. Body mass index, ALT, fasting insulin, homeostatic model assessment for insulin resistance, and triglyceride levels were significantly higher in liver biopsy-proven NAFLD than in the healthy group. The APRI, NAFLD fibrosis score, ALBI, AST-to-ALT ratio, FT3-to-FT4 ratio, and FIB-4 were significantly higher in the NASH cirrhosis group than in the healthy group. In patients with biopsy-proven NAFLD, the FT3-to-FT4 ratio was significantly lower than in the healthy group. Conclusion: The FT3-to-FT4 ratio is an effective and useful indicator to predict NAFLD/liver fibrosis and NASH cirrhosis severity.
Açıklama
Anahtar Kelimeler
FT3-to-FT4 Ratio, Liver Fibrosis Score, Non-alcoholic Fatty Liver Disease, Non-alcoholic Steatohepa-titis, Aspartate Aminotransferase, Alanine Aminotransferase, Fibrosis-4, Albumin–bilirubin Score, Free Triiodothyronine, Free Thyroxine
Kaynak
Journal of International Medical Research
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
49
Sayı
11
Künye
Türker, F., Oral, A., Şahin, T., Türker, B. Ç., Koçak, E., Ataoğlu, H. E., & Ahbab, S. (2021). Does the FT3-to-FT4 ratio easily predict the progression of NAFLD and NASH cirrhosis?. The Journal of international medical research, 49(11).
