Does the FT3-to-FT4 ratio easily predict the progression of NAFLD and NASH cirrhosis?

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dc.authorscopusidErdem Koçak / 15728184000
dc.authorwosidErdem Koçak / JGU-4032-2023
dc.contributor.authorTürker, Fatih
dc.contributor.authorOral, Alihan
dc.contributor.authorŞahin, Tolga
dc.contributor.authorÇavuşoğlu Türker, Betül
dc.contributor.authorKoçak, Erdem
dc.contributor.authorAtaoğlu, Hayriye Esra
dc.date.accessioned2021-11-16T05:55:03Z
dc.date.available2021-11-16T05:55:03Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Factors causing progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH) and liver cirrhosis remain relatively unknown. We aimed to evaluate the power and effectiveness of the free triiodothyronine (FT3)-to-free thyroxine (FT4) ratio to predict non-alcoholic fatty liver disease (NAFLD)/liver fibrosis and NASH cirrhosis severity. Methods: Patients (n = 436) with NASH-associated liver cirrhosis (n = 68), patients with liver biopsy-proven NAFLD (n = 226), or healthy participants (n = 142) were enrolled between January 2010 and January 2020. The aspartate aminotransferase-to-thrombocyte ratio (APRI), NAFLD fibrosis score, albumin-bilirubin score (ALBI), aspartate aminotransferase (AST)-to-alanine aminotransferase (ALT) ratio, FT3-to-FT4 ratio, and Fibrosis-4 (FIB-4) were calculated and evaluated. Results: All parameters were significantly higher in NASH cirrhosis than in the healthy group. Body mass index, ALT, fasting insulin, homeostatic model assessment for insulin resistance, and triglyceride levels were significantly higher in liver biopsy-proven NAFLD than in the healthy group. The APRI, NAFLD fibrosis score, ALBI, AST-to-ALT ratio, FT3-to-FT4 ratio, and FIB-4 were significantly higher in the NASH cirrhosis group than in the healthy group. In patients with biopsy-proven NAFLD, the FT3-to-FT4 ratio was significantly lower than in the healthy group. Conclusion: The FT3-to-FT4 ratio is an effective and useful indicator to predict NAFLD/liver fibrosis and NASH cirrhosis severity.en_US
dc.identifier.citationTürker, F., Oral, A., Şahin, T., Türker, B. Ç., Koçak, E., Ataoğlu, H. E., & Ahbab, S. (2021). Does the FT3-to-FT4 ratio easily predict the progression of NAFLD and NASH cirrhosis?. The Journal of international medical research, 49(11).en_US
dc.identifier.doi10.1177/03000605211056841en_US
dc.identifier.issue11en_US
dc.identifier.pmid34763561en_US
dc.identifier.scopus2-s2.0-85119442809en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1177/03000605211056841
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2236
dc.identifier.volume49en_US
dc.identifier.wosWOS:000720377700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoçak, Erdem
dc.language.isoenen_US
dc.publisherSage Journalsen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFT3-to-FT4 Ratioen_US
dc.subjectLiver Fibrosis Scoreen_US
dc.subjectNon-alcoholic Fatty Liver Diseaseen_US
dc.subjectNon-alcoholic Steatohepa-titisen_US
dc.subjectAspartate Aminotransferaseen_US
dc.subjectAlanine Aminotransferaseen_US
dc.subjectFibrosis-4en_US
dc.subjectAlbumin–bilirubin Scoreen_US
dc.subjectFree Triiodothyronineen_US
dc.subjectFree Thyroxineen_US
dc.titleDoes the FT3-to-FT4 ratio easily predict the progression of NAFLD and NASH cirrhosis?en_US
dc.typeArticleen_US

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