Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorPaskeh, Mahshid Deldar Abad
dc.contributor.authorEntezari, Maliheh
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2022-07-18T11:32:50Z
dc.date.available2022-07-18T11:32:50Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractCancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment. Graphical Abstract: [Figure not available: see fulltext.]. © 2022, The Author(s).en_US
dc.identifier.citationPaskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., . . . Ashrafizadeh, M. (2022). Emerging role of exosomes in cancer progression and tumor microenvironment remodeling. Journal of Hematology and Oncology, 15(1) doi:10.1186/s13045-022-01305-4en_US
dc.identifier.doi10.1186/s13045-022-01305-4en_US
dc.identifier.issn1756-8722en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85133004350en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13045-022-01305-4
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3007
dc.identifier.volume15en_US
dc.identifier.wosWOS:000819005700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofJournal of Hematology and Oncologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkeren_US
dc.subjectCanceren_US
dc.subjectExosomeen_US
dc.subjectImmunotherapyen_US
dc.subjectNon-Coding RNAen_US
dc.subjectPrognosisen_US
dc.titleEmerging role of exosomes in cancer progression and tumor microenvironment remodelingen_US
dc.typeReview Articleen_US

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