Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marmara University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 29–33°C. All prepared in situ gels showed non-Newtonian pseudoplastic flow (shear thinning system) like tear fluid at 32 ± 0.1ºC. The results of in vitro dissolution studies showed that at least 65% of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis.
Açıklama
Anahtar Kelimeler
Fusidic Acid, In Situ Gel, NaCMC, Ocular, Poloxamer
Kaynak
Journal of Research in Pharmacy
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
25
Sayı
1
Künye
Rencber, S., Ozcan Bulbul, E., Ustundag Okur, N., Ay Senyigit, . (2021). Journal of Research in Pharmacy
