Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application

Basit Öğe Kaydı
dc.authoridEce Özcan Bülbül / 0000-0001-7112-923X
dc.authorscopusidEce Özcan Bülbül / 57211920637
dc.authorwosidEce Özcan Bülbül / ACE-7724-2022
dc.contributor.authorRencber, Seda
dc.contributor.authorÖzcan Bülbül, Ece
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorAy Senyiğit, Zeynep
dc.date.accessioned2021-02-23T07:11:43Z
dc.date.available2021-02-23T07:11:43Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümüen_US
dc.description.abstractThis study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 29–33°C. All prepared in situ gels showed non-Newtonian pseudoplastic flow (shear thinning system) like tear fluid at 32 ± 0.1ºC. The results of in vitro dissolution studies showed that at least 65% of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis.en_US
dc.identifier.citationRencber, S., Ozcan Bulbul, E., Ustundag Okur, N., Ay Senyigit, . (2021). Journal of Research in Pharmacyen_US
dc.identifier.doi10.35333/jrp.2021.291en_US
dc.identifier.endpage12en_US
dc.identifier.issn2630-6344en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85100533117en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinid426372en_US
dc.identifier.urihttps://doi.org/10.35333/jrp.2021.291
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1491
dc.identifier.volume25en_US
dc.identifier.wosWOS:000610833200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorÖzcan Bülbül, Ece
dc.language.isoenen_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFusidic Aciden_US
dc.subjectIn Situ Gelen_US
dc.subjectNaCMCen_US
dc.subjectOcularen_US
dc.subjectPoloxameren_US
dc.titlePreparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic applicationen_US
dc.typeArticleen_US

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